There are plenty of changes coming when “Marvel’s Agents of S.H.I.E.L.D.” Season 4 premieres Tuesday. When the show left off, Hydra had finally been defeated and Lincoln sacrificed himself to save the world from a nuclear weapon. In a flash-forward to six months later, Daisy was revealed to have gone rogue, taking down banks and bridges. When the ABC drama returns, the team will still be looking for her, but they have other big problems on their hands. Here’s what you should know about the new season:

1. New Director — S.H.I.E.L.D. is going public again, and the director can’t be the man who died at the Battle of New York. Coulson (Clark Gregg) has to step down to make room for Jason O’Mara’s character (whose name is still being withheld).

2. Daisy’s Motives — The rogue agent (Chloe Bennet) left her team after Lincoln’s (Luke Mitchell) death, but she hasn’t stopped fighting for what’s right. A sneak-peek video from the premiere (above) reveals that she’s trying to take down the anti-Inhuman group, the Watchdogs. However, her reputation as Quake is making her seem more like a villain than a hero.

3. Ghost Rider — If you haven’t been paying any attention at all, you may have missed that Ghost Rider and his alter ego Robbie Reyes (Gabriel Luna) are joining the show. Ghost Rider isn’t an Inhuman, so his powers will definitely confuse Fitz (Iain De Caestecker) and Simmons (Elizabeth Henstridge). He might confound audiences a little bit too. It still isn’t clear if Ghost Rider is going to be good or evil. Gregg called him “the villain from hell,” but that could change.

4. Simmons’ Loyalty — The scientist has never been a rule breaker. She’ll get a promotion that allows her to work with the new director more, but her old team members might not like her allegiance to the boss.

5. Life-Model Decoy — At the end of Season 3, Radcliffe (John Hannah) was shown building Aida (Mallory Jansen), a life-model decoy (LMD). However, Marvel fans know that artificial intelligence doesn’t always benefit humanity. “It’s made very clear in ‘Age of Ultron’ when diving into the world of A.I. that things may not go as planned, so whether or not we continue that theme you will see,” executive producer Maurissa Tancharoen teased to Entertainment Weekly.

6. ‘Doctor Strange’ Connections — As usual “S.H.I.E.L.D.” will find a way to connect to the movie universe (despite the movies not acknowledging the shows). It won’t be quite as direct this year, though. “Doctor Strange” will explore the world of magic, and so will the ABC drama. “The same questions that our team is exploring leading up to the premiere of ‘Doctor Strange ,’ perhaps some of those concepts will be reflected in the movie and then carried through,” Tancharoen explained.

7. New Timeslot — Be sure to tune in at the right time! “Marvel’s Agents of S.H.I.E.L.D.” is on an hour later this year, at 10 p.m. EDT, and the new time will affect the story. The producers have promised a darker show.

“Marvel’s Agents of S.H.I.E.L.D.” Season 4 premieres Tuesday, Sept. 20, at 10 p.m. EDT on ABC.

Agents of SHIELD premiere Coulson (Clark Gregg) is going to struggle with having to answer to a new director in “Marvel’s Agents of S.H.I.E.L.D.” Season 4. Photo: ABC