Researchers at the Mount Sinai School of Medicine have found that Carvedilol, a drug generally prescribed to patients suffering from hypertension, might not just result in a decrease in the impact of brain degeneration caused due by the Alzheimer's syndrome but also promote healthy memory capability in old age.
Giulio Maria Pasinetti, the author of the research paper, holds the view that the study is very stimulating for future generations as it indicates that few drugs that are prescribed for hypertension and is already available in the market might be able to control memory functions in a way that reduces the pathological features of brain degeneration associated to Alzheimer's syndrome.
The team, led by Dr. Pasinetti, also discovered that Carvedilol, which is used for the treatment of blood pressure, has ability to influence the activities considerably decreases the brain degeneration and memory losses that one associates with the disease.
This breakthrough was achieved by genetically modifying the mice and to create conditions like Alzheimer's disease brain and the resultant degeneration and impairment of the memory without lowering the blood pressure. The study has since been published in the magazine Neurobiology of Aging.
In a related effort, the research team headed by Dr. Pasinetti analyzed the memory functions of mice by seeing how they learned newer tasks. In addition, it tested the recall power of the older information that had been chemically stored in the brain. This second study was published in the Journal of Alzheimer's Disease.
As part of the second study, the research team was able to find that the drug Carvedilol was proficient in helping memory functions that were based on learning newer tasks and knowledge as well as the ability to recall previously stored information in the brain.
The study was based on two groups of mice, one of which was on Carvedilol drugs. The researchers analyzed the behavior and learning patterns of both the groups and deduced that the mice that were on Carvedilol took lesser time to remember the tasks in comparison to the other group.
Dr. Pasinetti revealed that clinical researches were continuing are efforts were currently on to list out the exact the benefits of Carvedilol on aging. This may prove to be a vital agent in treating the symptoms of Alzheimer's disease. The research team was also preparing for carrying the tests forward from mice to human beings.