Arsenal can cut the Manchester United table lead to four points with a win at Emirates Stadium, but face a tough task in a Liverpool squad that is coming off a big win last week.
Arsene Wenger's squad is also coming off a victory, when Arsenal defeated Blackpool last week, 3-1, despite having 41-year-old Jens Lehman come to the rescue after a series of injuries to goalkeepers.
But Wenger received some much-need good news on the goalkeeping front. Wojciech Szczesny may return to man the nets for Sunday's match after recovering from a finger injury.
Central defender Johan Djourou, who at one point was expected to miss the remainder of the season with a shoulder injury, may also be available this weekend.
Arsenal will need all the reinforcements they can get against Liverpool. The Reds are riding high after a 3-0 victory over Manchester City at Anfield last week.
Liverpool will still be without Steven Gerrard and Daniel Agger. Defenders Martin Kelly and Glen Johnson continue to be sidelined, as well, with hamstring injuries.
Defender John Flanagan, who is only 18 years old, may be slotted into the starting line-up for this difficult road match.
The Reds have momentum after the Manchester City victory, as well as the quality play of new forwards Luis Suarez and Andy Carroll.
Liverpool still have a chance to finish ahead of Tottenham, who are only five points ahead in the standings.
But the Reds have struggled in London this season with a poor record of one win and five losses.
The Gunners have a tough road ahead of them. After their match with Liverpool, Arsenal will face London rivals Tottenham on Wednesday.