When and Where: The Barclays Premier League match kicks-from the Emirates at 7.45 a.m. ET. You can follow minute-by-minute coverage of the match below. A live stream will be available via ESP3. TV coverage will be provided by ESPN2.
Preview: Chelsea may have grabbed the headlines by taking a first-leg lead over Barcelona in their Champions League semi-final in midweek, but Saturday is all about qualification for next season's competition. And in that battle Arsenal hold the advantage.
The Gunners, currently in third, hold a seven point edge over sixth-place Chelsea, albeit with a game in hand.
For Chelsea, a defeat could all but end their hopes of qualifying for next year's Champions League, unless the Blues can win the competition. For Arsenal, a win would all but guarantee their annual sojourn to compete against Europe's best.
Arsene Wenger's men have recovered from a slow start to the season to turn their campaign around with some impressive recent performances. One of the results that showed that better times were on the horizon being their 5-3 victory at Stamford Bridge back in October.
But Arsenal suffered a setback last time out when they were beaten 2-1 by an in-form Wigan side.
Chelsea boss Roberto Di Matteo must hope his side can somehow get themselves up for another vital match after winning their FA Cup semi-final with Tottenham as well as gaining the advantage over Barcelona in the past seven days.
Team News: Arsenal will miss Mikel Arteta, who is out for the remainder of the season with an ankle injury. That blow is softened somewhat by the return to fitness of fellow-midfielders Abou Diaby and Francis Coquelin.
Laurent Koscielny is available after suspension, but Yossi Benayoun is ineligible against his parent club.
Chelsea will be without Didier Drogba with a knee injury picked up against Barcelona. David Luiz is still ruled out, while Baranislav Ivanovic continues to serve his domestic suspension.
Chelsea: Cech; Bosingwa, Cahill, Terry, Cole; Ramires, Essien, Meireles; Kalou, Mata, Torres
Arsenal: Szczesny; Sagna, Koscielny, Vermaelen, Santos; Song, Ramsey, Rosicky; Walcott, Gervinho, Van Persie
Prediction: It is unrealistic to think that Chelsea won't suffer some kind of comedown during their grueling schedule of crucial matches. Something's got to give and it could well be their league form that suffers as a result of the Blues' cup exploits.
With the prize of Champions League qualification in their grasp and an eagerness to make amends for the lapse against Wigan last time out, Arsenal should have enough to get the win.
Arsenal 2-1 Chelsea