Always concerned about maintaining his health, Kennedy regularly consults with a battery of Massachusetts General doctors.
Still, he maintains homes in both Boston and Washington and attends not only official events, but numerous others recognizing his family's political history.
Just last week, he and Caroline Kennedy awarded the annual "Profiles in Courage" award commemorating President Kennedy. And Friday, he attended a ribbon cutting at the New Bedford Whaling National Historical Park.
He was preparing to host the annual Best Buddies Challenge event on Saturday afternoon, a fundraiser for the Best Buddies organization founded by Anthony Kennedy Shriver that helps people with intellectual disabilities. The event attracted celebrities, including New England Patriots quarterback Tom Brady and Olympian Carl Lewis.
California Gov. Arnold Schwarzenegger and his wife, Maria Shriver, Kennedy's niece, said they appreciated all the messages of care they had received for the senator.
"It's always a comfort to the family to know that Sen. Kennedy is in the prayers of millions," their statement said.
Sen. John Kerry of Massachusetts, who went to the hospital, New York Sen. Hillary Rodham Clinton and Obama said were offering their prayers for his quick recovery.
Obama, beginning a tour of hospitals in Eugene, Ore., told reporters that he had been in touch with the senator's family. He said, "We are going to be rooting for him. I insist on being optimistic about how it's going to turn out."
A man walking by Massachusetts General was startled by the news when he asked about the reason for the large media presence. "Ted? Is he all right? Jeez, I'm taken aback. I just saw him on television yesterday," said Jerry Leonard, 76.
"He's a Kennedy. His name is synonymous with this area," the retired bartender said. "I'm a Bostonian, too, and he's done a lot for us around here and for the senior citizens in particular."

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