Russell 2000 adds 53 health care companies

Accelrys Inc., Acura Pharmaceuticals Inc., Adolor Corp., Almost Family Inc., Alphatec Holdings Inc., Ardea Biosciences Inc., Atrion Corp., Avant Immunotherapeutics, Caliper Life Sciences Inc., Cardiac Science Corp., Cardionet Inc., China Sky One Medical Inc., Clinical Data Inc., Columbia Laboratories Inc., Cougar Biotechnology Inc., Cytori Therapeutics Inc., Depomed Inc., Dexcom Inc., Dyax Corp., Exactech Inc., Five Star Quality Care, Hanger Orthopedic Group Inc., Idera Pharmaceuticals Inc., Immunogen Inc., Inspire Pharmaceuticals Inc. and Iris International Inc. were added to the Russell 2000.

Also joining the Russell 2000 were: Lexicon Pharmaceuticals Inc., Life Sciences Research Inc., Marshall Edwards Inc., Middlebrook Pharmaceuticals Inc., NPS Pharmaceuticals Inc., National Research Corp., Neogen Corp., Novavax Inc., Opko Health Inc., Optimer Pharmaceuticals Inc., Orthovita Inc., Pharmasset Inc., Questcor Pharmaceuticals Inc., Radnet Inc., Repligen Corp., Rexahn Pharmaceuticals Inc., Sangamo Biosciences Inc., Sequenom Inc., Somanetics Corp., Synovis Life Technologies Inc., Targacept Inc., Theravance Inc., Third Wave Technologies., U.S. Physical Therapy Inc., Vision-Sciences Inc. and Vnus Medical Technologies Inc.

PDL Biopharma Inc. moved down to the Russell 2000 from the large-cap Russell 1000.

The following health care companies were removed from the Russell 2000: Altus Pharmaceuticals Inc., American Dental Partners Inc., Animal Health International Inc., Aspect Medical Systems Inc., Bionovo Inc., Cutera Inc., Cytrx Corp., Genvec Inc., Hythiam Inc., Keryx Biopharmaceuticals inc., LCA-Vision Inc., MDRNA Inc., Minrad International Inc., Neurogen Corp., Northstar Neuroscience Inc., Novacea Inc., Penwest Pharmaceuticals Co., Poniard Pharmaceuticals Inc., Santarus Inc., Somaxon Pharmaceuticals Inc., Sonic Innovations Inc., Supergen Inc., Telik Inc., Trubion Pharmaceuticals Inc. and Vanda Pharmaceuticals Inc.

Biomarin Pharmaceutical, Hologic Inc., Illumina Inc., Inverness Medical Innovations Inc. and Perrigo Co., moved up to the Russell 1000, and were removed from the Russell 2000.

Tacoma, Wash.-based Russell Investments realigns the Russell 3000 index once per year, tracking what it maintains is 99 percent of the U.S. equity market. That index is then broken down to 26 smaller indexes, including the widely watched Russell 2000 index of small capitalization stocks.

The makeup of the Russell indexes for the next 12 months was finalized after the closing bell Friday.