NEW YORK - Pharmaceutical shares were front and center in premarket trading Monday as U.S. markets appeared headed for a mixed open following the holiday weekend.
German health care company Fresenius SE said it has agreed to buy U.S. generic drug maker APP Pharmaceuticals for $3.7 billion in cash, sending shares of APP up 36.1 percent to $24.26 in premarket trading.
The deal will give Fresenius more opportunities in North America for drugs administered intravenously. Fresenius shares fell $1.12 to $55.80.
Israel-based Teva Pharmaceutical Industries Ltd. saw its shares decline 6 percent to $44.38 after results from a late-stage study showed a higher dose of its multiple sclerosis drug Copaxone was not more effective than a lower, standard dose.
Shares of General Motors Corp. edged 3.2 percent higher to $10.44 after a report in The Wall Street Journal said that the struggling auto maker is considering job cut backs and closure of some of its brands in the wake of a prolonged U.S. sales slump. Last week, GM shares fell to levels not seen in more than 50 years.
Shares of media giant The Walt Disney Co. moved 2.3 percent lower to $30.17 after a Lehman Brothers analyst downgraded the shares to "Underweight" on the growing threat of digital distribution to its film and TV divisions, and the effects of weakness in the U.S. economy on its theme parks.
Belgian beverage company InBev resumed its aggressive bid for iconic U.S. brewer Anheuser-Busch Cos., announcing that the maker of Stella Artois will try to ouster the entire board of the maker of Budweiser Beer.
Anheuser shares rose 31 cents to $61.98 in early action.

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