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Amgen says osteoporosis drug successful in study



By AP
14 July 2008 @ 09:59 am EST

THOUSAND OAKS, Calif. - Biotechnology company Amgen Inc. said Monday late-stage study results show its developing osteoporosis drug was more successful than placebo at building bone density in men undergoing hormone therapy.

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The three-year study involved 1,400 men undergoing androgen deprivation therapy, which is often used to slow the growth of prostate cancer. A possible side effect of the treatment is osteoporosis, or loss of bone density, making fractures more common.

During the study, men receiving the experimental drug experienced a significantly higher increase in lower back bone density. The drug also met its secondary goal, which was reducing the number of lower back fractures.

Adverse events, or side effects, associated with denosumab were generally similar to side effects seen from patients taking placebo. However, denosumab patients had a 6 percent rate of serious infections, compared with 5 percent of patients taking placebo, Amgen said.

Shares of Amgen rose 60 cents to $51.62 in morning trading.

Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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