Tina Fey: Oprah and I 'Officially Best Friends'

Winfrey, 54, is guest starring as herself.

"Oprah Winfrey's presence on 30 Rock makes this episode a television event," Teri Weinberg, executive vice president, NBC Entertainment, said in a statement.

"She is a true legend in her own time, and in this comedy's tradition, it provides the perfect showcase for stars of her renowned status. We are all thrilled."

The daytime queen filmed her role last Saturday at the Silvercup Studios in Queens, N.Y., and it is being billed as one-shot appearance.

Tina Fey, the shows creator, executive and star said that "Oprah is very funny in the episode, and we are beyond grateful to have her."

"Also, I would like to announce that we are officially best friends," she joked.

This will be Oprah's second appearance on a primetime show. She first appeared as a therapist on the Ellen in 1997 when leading actress and comedian, Ellen DeGeneres came out publicly as a lesbian.