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NEW YORK (Reuters Health) - Among more than 2,500 people in France with a history of heart disease, taking B vitamins or omega-3 fatty acid supplements did not reduce the risk of developing cancer in a new study. In fact, for a small group of women, fish oil was linked to higher cancer risk.
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"We had expected to find a benefit of the supplements on cancer risk," said Valentina Andreeva, the study's lead author and a researcher at the University of Paris. "Instead, we found no effects in men, and some evidence of adverse effects in women."
Previous research has hinted that B vitamins might help protect people against cancer, especially colorectal cancer, though not all studies have agreed.
The original aim of Andreeva's trial was to test the effect of taking omega-3 fatty acids, vitamin B or both on cardiovascular disease in people with a history of heart attack or stroke.
To better understand whether the supplements might have additional effects, the group also collected information on how many trial participants developed cancer.
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The researchers had split the study subjects into four groups: one took two vitamin-B pills a day, another group took two pills of omega-3 fats, a third group took both supplements and a fourth group took fake pills that resembled the supplements.
The B vitamins were a mixture of 3 mg of B6, 0.02 mg of B12 and 0.5 mg of folic acid.
The participants assigned to take the omega-3 fats got 600 mg a day, with the supplements containing twice as much EPA as DHA.
For about five years Andreeva and her colleagues at the French national medical research institute, INSERM, tracked cancer diagnoses among the study subjects.
More than 2,000 people finished the study, and of these, 174 developed cancer and 58 died of it.
Those in the two groups that took B-vitamin supplements had the same risk of cancer as those who took the placebo pills.
These are in line with the findings of an even larger study of heart attack survivors, which also found B vitamins to be ineffective at reducing their risk of cancer (see Reuters Health story of June 22, 2010).
Similarly, men who took the omega-3 pills had the same risk of cancer as the men who took the placebo.
However, among women who took the omega-3 pills, the risk of cancer was three-fold.
