Explosions triggered a massive fire at Enterprise Products Mont Belvieu, Texas, plant at about 12:15 p.m. local time, according to local media reports on Tuesday.
KHOU-TV said the blaze at the plant located about 35 miles east of downtown Houston appeared to be burning out of control following a series of explosions.
Mont Belvieu is a major natural gas liquid storage hub.
There have been no initial reports of injuries.
An Enterprise Products representative was not immediately available to comment.
The Mont Belvieu plant is located north of the Houston Ship Channel and its row of crude oil refineries.
The blaze was having no effect on Ship Channel operations on Tuesday afternoon, the U.S. Coast Guard said.
(Reporting by Erwin Seba;editing by Sofina Mirza-Reid)