A protein called JAK was identified as a helper for the cancer cell to spread out of tumor into other parts of the body - a discovery that offers clues for new drugs to prevent cancers spreading.
Cancer Research UK-funded scientists have claimed that JAK protein can make cancer cell contract like a muscle, allowing them to move between tissues. Then the cancer cells would squeeze into tiny spaces and proliferate into a cancerous tumor and spread into new regions of the body.
Cancer, according to American Cancer Society, is the general name for a group of more than 100 diseases where cells in a part of the body begin to grow out of control. While normal body cells grow, divide and die in an orderly fashion, cancer cells continue to grow and form new, abnormal cells instead of dying. Cancer cells can also invade (grow into) other tissues, something that normal cells cannot do. Growing out of control and invading other tissues are what makes a cell a cancer cell, states the Society's website.
Around 90% of cancer-related deaths occur when the cancer spread beyond the initial tumor into other organs of the body, in a process called metastasis.
The finding raises the potential for drugs targeting JAK to stop the spread of tumors during metastasis.
Cancerous cells can move in two ways. In some cancer types the cancer cells use force to 'elbow' their way through the matrix. The force is produced by a process similar to muscle contraction. In other types of tumors, the tumor-associated healthy cells use force to create tunnels down which the tumor cells move.
The same processes are used to generate force in cancer cells and in the tumor associated normal cells, according to the scientists.
"We've shown that the same protein called JAK triggers tumor spread via two different routes - it generates the force needed for cancer cells to move around the body and also for triggers healthy cells in tumors to create furrows in tissues down which cancer cells move," said
Lead author Professor Chris Marshall, a Cancer Research UK-funded scientist from The Institute of Cancer Research.
Protein JAK has already been linked to leukemia, and some drugs in development are targeting the protein.
"Encouragingly drugs that block JAK are already in development to stop the growth of tumors. Our new study suggests that such drugs may also stop the spread of cancer," said Marshall.
"Discovering how cancer cells can funnel grooves though tissues, to squeeze away from primary tumors and spread to new sites, gives scientists fresh understanding of ways to stop cancer spread - literally in its tracks," says Dr Lesley Walker, Cancer Research UK's director of cancer information.