Manchester United has the advantage going into the second leg of the quarter finals after a Wayne Rooney first half goal gave them a 1-0 win at Stamford Bridge.
Rooney was at the end to side-foot a fine piece of football from Ryan Giggs deeming Chelsea to their first loss against United at the Bridge since 2002.
Chelsea manager Carlo Ancelotti paired both Didier Drogba and Fernando Torres in attack but Torres was unimpressive and Ancelotti faced criticism after substituting the much more effective Drogba instead of the dispirited Torres.
In Chelsea's best chance of the game, the Ivorian struck the post at the end of the first half and Patrice Evra was at hand to clear off the line after Frank Lampard got to the rebound. Controversy was rife at the end when Chelsea felt they were denied two penalties, one of which clearly was, and Ancelotti questioned the referee's courage after the match.