Manchester United seek to maintain their Premier League lead. Chelsea simply want to return to their early-season form and surpass Tottenham in the standings.
Those are the main storylines in what is expected to be an exciting match at Stamford Bridge.
The last time Manchester United and Chelsea played one another in a Premier League match, the Blues defeated the Red Devils 2-1. Joe Cole scored in the 20th minute, and Didier Drogba scored in the 79th minute. Federico Macheda scored for Manchester United in the 81st minute.
The last time Manchester United and Chelsea played one another in a Premier League match at Stamford Bridge, John Terry scored the lone goal in the 76th minute.
Dimitar Berbatov leads all scorers in the Permier League with 19 goals. Florent Malouda and Didier Drogba each have scored nine goals this season, and Fernando Torres also has nine goals -- all of them while playing for Liverpool.
The two teams will play each other again at Old Trafford on May 7.
Manchester United's next Premier League match will be on March 6 against Liverpool at Anfield.
Chelsea's next match will be against Blackpool at Bloomfield Road.
PROBABLE: Didier Drogba
OUT: Alex and Yossi Benyayoun
PROBABLE: Ryan Giggs, Michael Owen
OUT: Park Ji-Sung, Anderson, Antonio Valencia, Rio Ferdinand, Jonny Evans, Owen Hargreaves