The contest is set to get underway at 8:30 p.m. ET at the Georgia Dome. The game will be broadcast nationally on ESPN. If you can't get to a TV, you can watch a free live stream online at espn3.com.
It's Peyton Manning's second game since returning from multiple neck surgeries last year. After much speculation about how the quarterback would do with his new club, he had an impressive debut. Manning completed 73.1 percent of his passes for 253 yards and two touchdowns.
Denver started off the season at 1-0, defeating Pittsburgh 31-19 in their home opener. They'll have another tough task ahead of them as they visit Atlanta.
The Falcons had an even more impressive victory in Week 1, beating Kansas City by 16 points on the road. They're favored by three points and expected to win the contest.
With both quarterbacks playing well, the Broncos and Falcons could be in for a shootout.
Atlanta cornerback Brent Grimes was lost for the season last week with a torn Achilles. Without having to face the star defensive back, Manning could have another big performance. Look for Jacob Tamme and Eric Decker to play well.
The Broncos defensive backs will have to compete with one of the best receiving duos in the NFC. Julio Jones and Roddy White combined for 195 yards and two touchdowns in the opener.
The Falcons might have to rely on their passing game. Running back Michael Turner ran for only 32 yards on 11 rushes in the first game. The entire team only accumulated 84 yards on the ground.
Prediction: The game features two very good quarterbacks, so it should be close for most of the way. Manning looked like his old self against the Steelers, but Ryan has a few more weapons around him. The Falcons should win a close one.
Predicted Score: Atlanta 34, Denver 30