(REUTERS) -- The Dow and S&P 500 index fell at the open on Wednesday as the market continues to show signs of fatigue this week after a strong run from late last year, but the Nasdaq rose on forecast-beating results from Apple Inc .

The Dow Jones industrial average lost 42.92 points, or 0.34 percent, at 12,632.83. The Standard & Poor's 500 Index  dipped 2.18 points, or 0.17 percent, at 1,312.47. The Nasdaq Composite Index  added 13.41 points, or 0.48 percent, at 2,800.05.

(Reporting By Chuck Mikolajczak; editing by Jeffrey Benkoe)