Ahead of Saturday’s NFC East clash, the Philadelphia Eagles and Washington Redskins are dealing with several key injuries. Philadelphia is relatively healthy with 51 players on the active roster ready to roll, but will miss both linebacker Trent Cole and quarterback Nick Foles.

The Redskins have also ruled out two players in linebacker Gabe Miller and defensive end Jason Hatcher. And linebacker Keenan Robinson is listed as doubtful, while offensive tackle Trent Williams questionable according to the team’s official site. Due to a severely sprained toe, they also placed veteran safety Brandon Meriweather on the injured reserve list Friday, which ends his season early.

Third on the team with 6.5 sacks this season, Cole had surgery Wednesday for a broken bone in his hand and the team listed him as out against the Redskins. Along with sack-leader Connor Barwin and Vinny Curry, Cole helped make the Eagles the second best pass rushing team in the league with 47 sacks this season.

Instead the Eagles are expected to send out Brandon Graham to replace Cole. Graham’s totaled 5.5 sacks this season, and he’ll try to help Philadelphia keep Washington quarterback Robert Griffin III contained in the pocket.

Foles will miss his seventh straight game after breaking his collar bone, but he was seen participating some in practice earlier this week. Mark Sanchez will start in his place once again, and he’s gone 3-3 with a 10 touchdowns to nine interceptions.

Philadelphia’s lost two straight, including last week’s letdown to Dallas that dropped the Eagles into second-place in the division and in danger of missing out of the postseason.

The Redskins are 3-11 and bound for a top pick in next year’s draft, but they still pose a threat to Philadelphia’s playoff hopes.

Washington torched the Eagles defense for 511 yards when they met back in Week 3, and running back Alfred Morris is on pace for his third-straight 1,000-yard season. Philadelphia is 18th against the run, allowing 113.9 yards per game, and even with Griffin dealing with nagging injuries and feuding with head coach Jay Gruden he’s still a threat both in and out of the pocket.

Washington will miss Hatcher for the second straight game due to inflammation in his right knee, and he told the Washington Post he could sit out next week’s matchup against Dallas as well. Third-year defensive end Frank Kearse is next up on the depth chart and could get more time against the Eagles.

Williams injured his shoulder against the New York Giants last week, and Washington’s expected to shift around tackles Tom Compton and Tyler Polumbus to fill the void.

Start Time: 4:30 P.M. ET

TV Channel: NFL Network

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Betting Odds: Philadelphia -8

Over/Under: 51 points

Prediction: Philadelphia over Washington, 31-24