When and Where: The Premier League match kicks off from Goodison Park at 4 p.m. ET. The match will be shown on Fox Soccer Plus. The game will also be available to watch in its entirety online from 11.59 p.m. at FoxSoccer2Go.
Preview: Arsenal come into Wednesday's contest in a rich vein of form, after winning their last three games in the Premier League.
With Chelsea facing a difficult match away to Manchester City, also on Wednesday, Arsenal will see this as a great opportunity to extend their three point advantage over the Blues for that all-important fourth Champions League spot.
The Gunners should also be well rested having not played since the dramatic 2-1 over Newcastle over a week ago.
In contrast, Everton have played twice in the past eight days and could show the effects against Arsenal.
After a 3-0 defeat to Liverpool last time out in the league Everton need to guard against their Premier League campaign fizzing out, with the club currently nestled in mid-table.
Team News: Everton boss David Moyes strongly hinted in the Merseyside derby last week that he is prioritizing the FA Cup, after resting several players for the game.
It would be no surprise if Moyes again decides to switch things up here, following the 1-1 draw against Sunderland in the FA Cup quarter-final on Saturday.
Steven Pienaar is one of those likely to come into the side after being cup-tied at the weekend, while Phil Jagielka could return in defense.
Arsenal have no new injury worries going into the match. Manager Arsene Wenger will have to decide whether to bring Aaron Ramsey back into the side, or stick with the team that triumphed over Newcastle, with Alex Song and Mikel Arteta anchoring the midfield behind a three of Tomas Rosicky, Alex Oxlade-Chamberlain and Theo Walcott.
Prediction: Finally getting players fit and having a more settled lineup is crucial for Arsenal and explains much of their good recent form.
There is now more solidity at the back and the in-form Rosicky and emergent Oxlade-Chamberlain have added an extra creative element to add to the goals of Robin van Persie.
Everton are a good side at their best, but there is the suspicion that at least one eye is now focused on the FA Cup, with little but respect, and money, to play for in the Premier League.
After 10 years at the club Moyes looks like he wants to mark his time at Goodison Park with a trophy.
Everton 1-2 Arsenal