In the most significant change to U.S. cigarette packs in 25 years, the Food and Drug Administration unveiled new warning labels that depict in graphic detail the negative health effects of tobacco use.

The FDA says the new labels will clearly and effectively convey the health risks of smoking aimed at encouraging current smokers to quit and disuade nonsmokers from starting.

These labels are frank, honest and powerful depictions of the health risks of smoking, Health and Human Services Secretary Kathleen Sebelius said in a statement.