Serena Williams
Serena Williams is looking to win her 22nd Grand Slam title. Getty

Serena Williams has a chance to make history in Saturday's French Open final, as she faces Garbine Muguruza with a chance to tie Steffi Graff for the most Grand Slam championships in the Open Era. But Williams will attempt to draw even with the famed German at her least successful Grand Slam.

While Williams has won the Australian Open, Wimbledon and the U.S. Open six times each, she has "only" won three times on the red clay of Roland Garros. But Williams has been on a hot streak, winning 47-of-50 matches at majors.

serena wave
Serena Williams will be looking to make history at Roland Garros on Saturday. Getty

The 31-year-old will also have a chance to avenge the most lopsided defeat of her career. At the 2014 French Open, Williams was upset 6-2 6-2 in the second round by Muguruza, then just 20 years old. Williams and Muguruza also met in the Wimbledon final, with Williams prevailing 6-4 6-4, and Williams has defeated the Spaniard on three other occasions.

"Serena and I are players who like dictating the game," Muguruza said. "There will be moments when she'll be dominating, and maybe at times I will be dominating. I think I can be a tough opponent, too."

Muguruza defeated Samantha Stosur 6-2 6-4 to reach the final, while Williams had some struggles with unseeded Kiki Bertens in the semifinals, 7-6 (9-7) 6-4.

Williams is favored to win. According to oddschecker, she has a 4/7 chance of taking home the title, compared to Muguruza, who has 6/4 odds. There is a chance of rain in Paris on Saturday, with a forecast of cloudy weather.

Start Time: 9 a.m. ET

TV Channel: NBC

Online Stream: NBC Sports Live Extra