Gilmore Girls creator Amy Sherman-Palladino will be tackling more mother-daughter relationships in a project for HBO.

Sherman-Palladino will write and executive produce an untitled comedy-drama for the cable network. The show chronicles the complicated relationships among three adult sisters, all writers living in the same Upper East Side apartment building, and their mother, a domineering literary lioness who reserves her affections for their ne'er-do-well brother.

It's a story of love, hate, family -- and finding the perfect opening line, Sherman-Palladino said.

The project marks Sherman-Palladino's first foray into cable.

After a string of jobs on broadcast sitcoms, including Roseanne and Veronica's Closet, Sherman-Palladino rose to prominence with her quirky mother-daughter comedy-drama Gilmore Girls, which aired on the WB and CW for seven seasons. For the first six years, Sherman-Palladino executive produced the show starring Lauren Graham and Alexis Bledel before parting ways with producing studio Warner Bros. TV.

Sherman-Palladino most recently created and executive produced the short-lived Fox comedy series The Return of Jezebel James.