The New York Daily News reported Hillary and Bill Clinton, the former president, and their daughter, Chelsea, left New York-Presbyterian Hospital in a black van, escorted by three black SUVs, around 6:20 p.m. EST.
The secretary of state, wearing a grey scarf, “had a stoic expression on her face and looked pale,” according to the paper.
Clinton, who had not been seen in public since Dec. 7, was at New York-Presbyterian for treatment of a blood clot behind her right ear that stemmed from a concussion suffered in mid-December, the department announced Sunday.
The concussion was the result of an earlier illness, described by the State Department as a stomach virus she had picked up during a trip to Europe that led to dehydration and a fainting spell after she returned to the United States.
"Secretary Clinton was discharged from the hospital this evening. Her medical team advised her that she is making good progress on all fronts, and they are confident she will make a full recovery," Philippe Reines, a deputy assistant secretary of state, said in a statement reported by Reuters.
Reines said Clinton was "eager to get back to the office."
In a statement released by the State Department on Monday, Clinton's doctors said she was being treated with blood thinners and would be released from the hospital once the correct dosage had been set.
The type of blood clot Clinton has is called a cerebral vein thrombosis and is relatively rare, Dr. Mary Cushman, director of the Thrombosis and Hemostasis Program at the University of Vermont and chair of the American Society of Hematology's subcommittee on quality of care, told CNN.
A two-year study conducted in the Netherlands found cerebral vein thrombosis affects approximately 1 in every 100,000 people. In comparison, the Centers for Disease Control and Prevention says 1 in 1,000 people are affected by deep venous thrombosis (DVT) -- a similar clot found most often in the leg.
Clinton, now 65, suffered from a DVT in 1998. Anyone who has had a blood clot in the past is at a higher risk of getting one again. About one-third of people with DVT will have a recurrence within 10 years, according to the CDC.