Kirsten Dunst and Orlando Bloom will co-star in Roger Donaldson's Cities.
The pair teamed up once before for Cameron Crowe's critically maligned Elizabethtown, with decidedly uneven results.
They join a previously announced Clive Owen and Anil Kapoor in the thriller, a genre that Donaldson, the director of No Way Out and Thirteen Days, has had success with in the past.
Matthew Metcalfe and Chris Curling will produce.
Lisa Wilson's Parlay Films is handling international rights to the film that is set to shoot in Spring 2012. The film will shoot in multiple cities, including London, Mumbai and New York.
After a post-Spider-Man career hiatus, Dunst has been re-establishing herself in the industry with a series of roles in independent films such as Lars von Trier's Melancholia and All Good Things.
Bloom is currently filming Peter Jackson's The Hobbit and has a supporting role in the box-office disappointment The Three Musketeers.