Madonna slammed gay designers Domenico Dolce and Stefano Gabbana over their comments calling children born through the method of in vitro fertilization (IVF) “synthetic.” Last week, the duo had said in an interview to Italy’s Panorama magazine that gay couples should not be allowed to adopt. 

In response, the 56-year-old singer posted a Dolce & Gabbana 2010 campaign photo, which featured her along with a baby. “All babies contain a soul however they come to this earth and their families. There is nothing synthetic about a soul!! So how can we dismiss IVF and surrogacy? Every soul comes to us to teach us a lesson. God has his hand in everything even technology! We are arrogant to think Man does anything on his own. As above so below! Think before you speak,” Madonna, who is the latest celebrity to condemn the designer duo's comments, said in the caption of the photo posted on Instagram.

In an interview with CNN on Wednesday, the Italian fashion designers addressed the controversy. "I believe in the traditional family," Dolce told CNN, adding that his views on IVF were private. "It is impossible to change my culture for something different. It's me... I respect all the world, all the culture."

The comments triggered outrage and several celebrities who supported their brand voiced their objection. Singer Elton John called for a boycott of the fashion brand.

“We oppose gay adoptions. The only family is the traditional one. No chemical offsprings and rented uterus: life has a natural flow, there are things that should not be changed,” the designers had reportedly said.