When and Where: The Premier League encounter gets underway from Old Trafford at 3 p.m. ET. A live stream is available via ESPN3. TV coverage will be on ESPN2.
Preview: Five wins on the bounce in the Premier League has given Manchester United the advantage in the title race. But there is no room for slip-ups against Fulham on Monday with the opportunity to go three points clear at the top.
Antonio Valencia was in inspired form in the 5-0 win at Wolves last time out and the Ecuadorian winger's return from injury could be invaluable as United look to retain the Premier League title.
Fulham have been fairly inconsistent all season long, as shown by defeats in their last two matches following a win of three straight victories.
Currently on 36 points, Fulham are almost certainly safe from relegation but should be aiming to push into the top-half of the Premier League by the season's conclusion.
Team News: United have no new injury worries, after an eight-day break since their last outing. Tom Cleverley, Phil Jones, Chris Smalling, Paul Pogba and Fabio all got match time to improve their fitness in a reserve-team match last week.
There is competition in the right-back slot with Rafael, Fabio, Jones and Smalling all in contention. While Sir Alex Ferguson may again select Danny Welbeck ahead of Ashley Young to support Wayne Rooney and Javier Hernandez from the left wing.
Although Fulham have recently adopted an attacking formation with Moussa Dembele in midfield supporting Andrew Johnson and Pavel Pogrebnyak up front. At Old Trafford, though, expect Martin Jol to stiffen the midfield with Danny Murphy coming in, possibly at the expense of Johnson.
Prediction: All signs point to a United win on Monday. The form of the two sides, coupled with Fulham's poor away record once again this season, as well as their 5-0 drubbing to United at Craven Cottage earlier in the campaign do not give the Cottagers much hope of springing an upset.
This should be a fairly comfortable United victory.
Manchester United 2-0 Fulham