German Chancellor Angela Merkel said Wednesday in some of her most dramatic rhetoric since the euro zone crisis erupted two years ago that it was high time for Europe to achieve a breakthrough on changes to its ground rules.

Speaking at a conference in Berlin, Merkel said the situation in Europe had become unpleasant and the bloc would not survive unless it showed the world it was capable of adapting to the debt crisis that has intensified in recent weeks, sparking speculation of a euro zone breakup.

Her remarks appeared aimed at winning over sceptical European partners to a German push for changes to the bloc's Lisbon Treaty, rather than a signal that Berlin was ready to consider radical new measures to stem the crisis.

It is time for a breakthrough to a new Europe, Merkel said. A community that says, regardless of what happens in the rest of the world, that it can never again change its ground rules, that community simply can't survive. I'm convinced of this.

Because the world is changing so much, we must be prepared to answer the challenges. That will mean more Europe, not less Europe.

Italian borrowing costs shot up Wednesday despite a promise by embattled Prime Minister Silvio Berlusconi to step down. Europe's rescue fund is not big enough to cope with a bailout of Italy and the market moves raised alarm bells across the bloc, with Merkel's spokesman Steffen Seibert admitting they were grounds for concern.

We are watching developments in Italy with great interest, he said.

The latest turmoil has forced policymakers to consider more radical solutions for solving their crisis. At a G20 summit in Cannes last week, Merkel and French President Nicolas Sarkozy conceded for the first time that Greece might have to leave the 17-nation currency bloc at some point.

Former German foreign minister Joschka Fischer, a longtime supporter of European integration, said in a newspaper interview Wednesday the 27-nation EU was too unwieldy and that it was time think about forming a smaller group capable of pursuing needed reforms.

Berlin hopes that by taking a rapid leap-forward on the EU's fiscal stability rules, the bloc might win back the confidence of the markets. But even German officials admit that changing the EU treaty could take up to a year on the most ambitious projections.

Some European sources have suggested that more radical steps may be needed if markets cannot be won over soon, including the idea of moving forward with a smaller group of euro zone members.

the situation in Europe is so unpleasant now that it is time for a change and called for changes in the European Union Treaty.

Merkel said in a speech that declarations of good intent are no longer good enough and that genuine structural reforms are needed that can be checked.

Merkel said the political community will not survive if it is not capable of changing. She said countries' responsibilities cannot end at their frontiers.

She also said that reforms are needed quickly because the rest of the world is not waiting for Europe.