Headlined by all the Chicago Cubs in starting infield and all the Boston Red Sox in the starting outfield , Major League Baseball’s biggest stars will storm the field as the National League and American League battle Tuesday night at Petco Park in San Diego. 

While enjoying a special run in the first half of the season with the fourth-best record in the majors, the Cubs were honored by fans with five players voted into the starting lineup. First baseman Anthony Rizzo, second baseman Ben Zobrist, shortstop Addison Russell, and third baseman Kris Bryant will cover the infield, while outfielder Dexter Fowler would have made it five total Cubs before he was hurt.

With the Washington Nationals’ Bryce Harper leading the outfield, and Fowler and the New York Mets Yoenis Cespedes both injured, the Miami Marlins' Marcell Ozuna will fill in for Fowler and the Colorado Rockies' Carlos Gonzalez for Cespedes.

It’s a towering and stacked lineup for NL and Mets manager Terry Collins, who will also send San Francisco Giants ace Johnny Cueto out to the mound as the starting pitcher. The 30-year-old Dominican has posted an impressive 13-1 record over 18 starts with a 2.47 ERA and a 115 strikeouts.

Over in the AL, the Red Sox will also roll out four starters, including two-thirds of the outfield. Jackie Bradley Jr. and Mookie Betts will each make their All-Star debuts, as will shortstop Xander Bogaerts for a Boston offense that leads the majors in runs and nearly every other offensive category.

And MVP candidate David Ortiz will also serve as the starting designated hitter in his 10th All-Star appearance. The 40-year-old Ortiz is enjoying an incredible season and ranks second in the AL in batting average (.332) and RBI (72).

Led by defending World Series champion manager in the Royals' Ned Yost, the AL will counter Cueto with the Chicago White Sox Chris Sale. Making his fifth All-Star game, Sale ended the first-half with a league-best 14 victories over 125 innings and three complete games.

The NL is favored by 1.5 runs and it may be a high-scoring affair with the over/under set at 7.5 runs, according to Sportsbook.ag. The winning squad will lock up home-field advantage throughout the World Series later this fall.

The AL is seeking its fourth straight victory, and third consecutive win on the NL's turf. Last year the Los Angeles Angels Mike Trout earned MVP honors in a 6-3 win at Great American Ball Park in Cincinnati.

Start Time: 8 p.m. ET

Actual Start Time: After the national anthem and ceremonies, Sale should fire off the first pitch at roughly 8:10 p.m. ET.

TV Channel: FOX

Live Stream: FoxSportsGo