The game begins at 1pm eastern time and will be shown by FOX, or watch a live stream online by purchasing NFL Sunday Ticket Max.
New York's depleted secondary was scorched by Tony Romo and the Dallas Cowboys for 307 yards and three touchdowns en route to a 24-17 loss for the defending champions.
The Cowboys punished the Giants with quick slant routes, benefiting Dallas receiver Kevin Ogletree, who made eight receptions for 114 yards and two touchdowns. Fellow receiver Dez Bryant contributed four receptions for 85 yards.
New York quarterback Eli Manning was 22-for-29 for 213 yards and a touchdown, but wide receiver Victor Cruz dropped three balls on key drives. Cruz eventually made six grabs for 58 yards, but did not look like the receiver he was last season.
New York's defense also failed to contain running back DeMarco Murray, who had 131 yards rushing.
Home field advantage may be nulled for the Giants Sunday, who are 25-23 at home and 32-17 on the road since 2006.
The Buccaneers had a much stronger start to their season by breaking a 10-game losing streak dating back to last season with a 16-10 victory over NFC South foe Carolina Panthers.
Rookie running back Doug Martin marched down 95 yards on 25 carries, and Tampa Bay held Carolina to only 10 rushing yards on the day despite the mobility of quarterback Cam Newton.
The Buccaneers defense kept Newton in the pocket, made him beat them with his arm, and sacked him three times. Wide receiver Steve Smith did make seven catches for 106 yards, but Tampa Bay denied him the end zone.
New York could be down without cornerback Prince Amukamara for a second straight week, and defensive tackle Marvin Austin and linebacker Keith Rivers are listed as probable.
Betting Odds: New York is favored by 7 points.
Prediction: Tampa Bay's defense appears rejuvenated by new head coach Greg Schiano, and could force Manning into poor decisions. The Giants have to get their rushing attack going as they only gained 82 yards against Dallas.
Predicted Score: New York 18, Tampa Bay 9