The 2016 NFL season begins with a rematch of Super Bowl 50 on Thursday night when the Carolina Panthers visit the defending champion Denver Broncos. It might be the best game on the Week 1 schedule, which features just one other contest that involves two teams that made the playoffs last year.

Even though the Broncos won the 2016 Super Bowl in blowout fashion, they enter the season opener as three-point underdogs at home. Trevor Siemian replaces the recently retired Peyton Manning, getting his first ever start at quarterback, and Carolina quarterback Cam Newton is back after winning last season’s MVP award.

While Thursday Night Football features the two teams that won last year’s conference championship games, Sunday Night Football is a matchup of the losers from the AFC and NFC title game. If the game was set to take place after Week 4, the Arizona Cardinals would be small favorites over the New England Patriots. But Tom Brady’s absence because of his four-game suspension has made the Patriots six-point underdogs on the road.

Nine of the 16 games feature a betting line of three points or less. The contest between the New York Giants and Dallas Cowboys is the only pick’em on the schedule. The early betting odds had Dallas favored at home, but the line shifted when Tony Romo suffered an injury that’s expected to keep him out between six and 10 weeks.

Only one team in the opening week is favored by more than a touchdown. The Seattle Seahawks are giving the visiting Miami Dolphins 10.5 points. Seattle is among the favorites to represent the NFC in the 2017 Super Bowl.

Russell Wilson Seattle Seahawks Russell Wilson and the Seattle Seahawks are easily the biggest favorites in Week 1 of the 2016 NFL season. Photo: Getty

Sunday’s contest between the Oakland Raiders and New Orleans Saints is expected to be the week’s highest-scoring game with an over/under of 51. Two games have an over/under of 41.

Below are the complete betting lines for all the Week 1 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

Carolina Panthers (-3) at Denver Broncos, 42

Tampa Bay Buccaneers (+3) at Atlanta Falcons, 47.5

Minnesota Vikings (-2) at Tennessee Titans, 41

Cleveland Browns (+4) at Philadelphia Eagles, 41

Cincinnati Bengals (-2.5) at New York Jets, 41.5

Oakland Raiders (+1) at New Orleans Saints, 51

San Diego Chargers (+7) at Kansas City Chiefs, 44.5

Buffalo Bills (+3) at Baltimore Ravens, 44.5

Chicago Bears (+6.5) at Houston Texans, 44

Green Bay Packers (-4.5) at Jacksonville Jaguars, 48

Miami Dolphins (+10.5) at Seattle Seahawks, 44

New York Giants (PK) at Dallas Cowboys, 46

Detroit Lions (+4) at Indianapolis Colts, 50.5

New England Patriots (+6) at Arizona Cardinals, 47

Pittsburgh Steelers (-3) at Washington Redskins, 50

Los Angeles Rams (-2.5) at San Francisco 49ers, 44