Several playoff contenders were defeated in Week 3, but they are expected to bounce back with big wins in Week 4 of the 2016 NFL season. Four of the biggest favorites on the upcoming schedule are coming off losses, including three of last year’s division winners.

The Pittsburgh Steelers and Arizona Cardinals are both significant favorites after suffering embarrassing defeats on the road. Following a 31-point loss in Philadelphia, the Steelers are giving the visiting Kansas City Chiefs 5.5 points. The Los Angeles Rams are 8.5-point underdogs in their visit to Arizona, who lost by 15 points to the previously winless Buffalo Bills.

The Cincinnati Bengals and Houston Texans are both favored by more than six points after losing to the AFC’s best teams. Cincinnati starts Week 4 with a game against the Miami Dolphins on “Thursday Night Football,” and Houston hosts the Tennessee Titans in their first divisonal matchup of 2016.

The Washington Redskins are the biggest favorites in Week 4, coming off their first win of the season. They are giving the 0-3 Cleveland Browns 9.5 points.

Amid concerns that some of the NFL’s best quarterbacks might be sidelined in Week 4, betting lines are unavailable for a couple of games on the upcoming schedule. Russell Wilson suffered a sprained MCL ahead of the Seattle Seahawks’ visit to the New York Jets, and Cam Newton twisted his ankle last week. Both signal callers are hopeful to play on Sunday, and their teams will likely be road favorites if Wilson and Newton are on the field.

The New England Patriots will definitely be without their No.1 quarterback when they host the Bills. Tom Brady will serve the final game of his suspension on Sunday, but it’s unknown whom the Patriots will start at quarterback because both Jimmy Garoppolo and Jacoby Brissett are battling injuries.

Week 4 marks the first bye week of the season. The Philadelphia Eagles and Green Bay Packers are both off after wins at home.

Carson Palmer Arizona Cardinals Carson Palmer and the Arizona Cardinals are heavy favorites in Week 4 after losing to the Buffalo Bills at New Era Field on Sept. 25, 2016 in Orchard Park, New York. Photo: Getty

Below are the complete betting lines for all the Week 4 games, including the point spreads and totals. These are the consensus odds from multiple sportsbooks in Las Vegas and online, via OddsShark.

Miami Dolphins (+7) at Cincinnati Bengals, 44.5

Indianapolis Colts (-2.5) at Jacksonville Jaguars, 49.5

Cleveland Browns (+9.5) at Washington Redskins, 45.5

Buffalo Bills (N/A) at New England Patriots, N/A

Seattle Seahawks (N/A) at New York Jets, N/A

Carolina Panthers (N/A) at Atlanta Falcons, N/A

Detroit Lions (-3) at Chicago Bears, 46.5

Tennessee Titans (+6.5) at Houston Texans, 40.5

Oakland Raiders (+3.5) at Baltimore Ravens, 46.5

Denver Broncos (-3) at Tampa Bay Buccaneers, 44.5

Dallas Cowboys (-3) at San Francisco 49ers, 46

New Orleans Saints (+4) at San Diego Chargers, 52

Los Angeles Rams (+8.5) at Arizona Cardinals, 43

Kansas City Chiefs (+5.5) at Pittsburgh Steelers, 47.5

New York Giants (+4) at Minnesota Vikings, 43.5