Injuries to Buffalo Bills running back Fred Jackson and San Diego Chargers tight end Antonio Gates will leave many owners scrambling for a quick band aid.
If you did lose Jackson or one of your running backs underperformed like Tennessee's Chris Johnson, you can try to plug a tight end or extra receiver into your flex spot to make up the difference.
The biggest temptation is to add Dallas Cowboys wide receiver Kevin Ogletree, but only one owner can land Week 1's breakout performer. If you can pick him up do it, but there are plenty of wide receivers to choose from as more and more teams focus their offense on the passing game.
Rather than grabbing the flashiest pick-up of the week, look into the below players, whose value can increase throughout the season.
Dennis Pitta, TE, Baltimore Ravens
Gates' injury leaves many owners in need of a tight end. Pitta benefits from the Ravens new no-huddle offense, and his play Sunday should make him a consistent target for quarterback Joe Flacco. Pitta grabbed five balls for 73 yards and a touchdown, and Baltimore's offense looked unstoppable in Week 1.
Alfred Morris, RB, Washington Redskins
With Buffalo running back Fred Jackson out for up to three weeks, everyone will make a run on C.J. Spiller. Look for Morris instead, who benefited from head coach Mike Shanahan's proven rushing attack Sunday with 96 yards and two touchdowns on 28 carries. Defenses will have to decide whether to stop Morris or quarterback Robert Griffin III.
Rod Streater, WR, Oakland Raiders
Streater fumbled after recording his first career reception Sunday, but the rookie out of Temple settled down and scored Oakland's only touchdown, then got in the end zone again for a 2-point conversion. Over the course of the season, Streater could prove to be a viable No. 2 receiver or flex spot addition. If you are in a PPR league, Streater makes receptions in bunches, grabbing 18 balls during the preseason.
Stephen Hill, WR, New York Jets
The Jets surprised everyone with their 48-28 onslaught against Buffalo, and Hill was a major factor. The second-round draft choice made five receptions for 89 yards and two touchdowns, and benefits from defenses keying on receiver Santonio Holmes.
Alshon Jeffrey, WR, Chicago Bears
After snatching three receptions for 80 yards and a touchdown Sunday, Jeffrey turned himself into a commodity for any owner looking for more depth at the receiver position.