Marshawn Lynch
The Seahawks and 49ers are both double-digit favorites in Week 6. Reuters

The upcoming schedule of NFL games features the largest betting lines of the 2013 season. The Broncos are the biggest favorites in history, while six other teams are giving their opponents at least a touchdown.

Week Five was an impressive showing for the underdogs. The favorite failed to cover in seven of the 14 contests, and six of them lost outright. Below are picks against the spread for every contest in Week Six.

New York Giants (+7.5) at Chicago Bears

Each week, the Giants look to turn their season around, but they’ve yet to prove that they can even be competitive against a good team. New York’s 20 turnovers are almost twice as many as the No.2 team in that category. Considering that the Bears are one of the best in the NFL at forcing takeaways, this game could get out of hand in a hurry.

Prediction ATS: Chicago

Oakland Raiders (+9) at Kansas City Chiefs

They’re only 2-3, but the Raiders have been undervalued in 2013. Terrell Pryor has played well, recording a 97.6 passer rating and rushing for 229 yards. The Chiefs will likely win, but the Raiders are 4-0 against the spread when Pryor starts.

Prediction ATS: Oakland

Philadelphia Eagles (-1) at Tampa Bay Buccaneers

The Buccaneers are one of four winless teams, but they have been in almost every game. Three of their four losses have come by three points or less. Tampa’s defense is one of the league’s best and facing Nick Foles at starting quarterback could be what they need to get their first victory.

Prediction ATS: Tampa Bay

Green Bay Packers (-3) at Baltimore Ravens

The Ravens haven’t exactly looked like the team that won the Super Bowl last year, but they’ve remained very good at home. The Packers are banged up and will be without Clay Matthews, James Starks and Brad Jones. Cornerback Casey Hayward could also sit with hamstring injury. Joe Flacco could be in line to have his best game of the young season.

Prediction ATS: Baltimore

Detroit Lions (-2.5) at Cleveland Browns

Last week, the Lions found out just how much their offense can be affected without Calvin Johnson in the lineup. With the wide receiver continuing to miss practice, the odds of him playing in Week Six don’t look good. Brandon Weeden was effective in his return, and the Browns should be able to take advantage of the Lions injury woes.

Prediction ATS: Cleveland

Carolina Panthers (+2.5) at Minnesota Vikings

The Vikings have only one victory, but they’ve been in every game. Injecting Matt Cassel into the starting lineup seems to have given the offense a boost. Cam Newton has struggled in 2013 and that could continue in Minnesota.

Prediction ATS: Minnesota

St. Louis Rams (+7.5) at Houston Texans

Matt Schaub has played as poorly as any quarterback in recent weeks and was nearly benched after his three-interception performance against the 49ers. The Rams may be mediocre at best, but it’s hard to take the Texans when they’re favored by more than a touchdown with Schaub at the helm.

Prediction ATS: St. Louis

Pittsburgh Steelers (+2.5) at New York Jets

Geno Smith has made plenty of rookie mistakes, but he’s also led the Jets to three victories. The Steelers can’t move the ball on offense, and playing against a tough New York defense won’t help.

Prediction ATS: New York

Cincinnati Bengals (-7) at Buffalo Bills

The Bengals have a few marquee wins on their schedule, but they’ve played much worse on the road. Likewise, the Bills have thrived at home. It won’t be easy for Buffalo to steal a victory with Thad Lewis at quarterback, but E.J. Manuel didn’t put up tremendous numbers in the first five games. They have enough on defense and in the running game to keep it close.

Prediction ATS: Buffalo

Tennessee Titans (+13.5) at Seattle Seahawks

In five of their last six home games, the Seahawks have won by at least 21 points. With Ryan Fitzpatrick starting, the Titans are a below-average offensive unit. They’ll have trouble getting on the board on Sunday.

Prediction ATS: Seattle

Jacksonville Jaguars (+27.5) at Denver Broncos

The Jaguars may be the worst team in football, but the Broncos will have their work cut out for them in trying to cover the largest point spread in league history. Since the NFC-AFC merger, nine teams have been favored by 20 points or more, and only one has covered. The Broncos have been susceptible against the pass, and Chad Henne should be able to lead Jacksonville to a late touchdown or two.

Prediction ATS: Jacksonville

Arizona Cardinals (+10.5) at San Francisco 49ers

The Cardinals have gotten off to a good start by winning three of their first five games and going 4-1 against the spread. However, in their one game against an upper echelon team, they lost to the Saints by 24 points. The 49ers have won their last two games by 57 total points, and they should be able to take advantage of Carson Palmer’s mistakes, who’s second in the league in interceptions.

Prediction ATS: San Francisco

New Orleans Saints (+2.5) at New England Patriots

In the only game that the Saints didn’t cover the point spread, they finished just one point shy of the betting line. The Patriots are no longer the offensive juggernaut they once were, exemplified by the Bengals ending Tom Brady’s touchdown streak. New England should get a boost as Rob Gronkowski returns to the lineup, but the Saints’ top five defense won’t make it easy for them.

Prediction ATS: New Orleans

Washington Redskins (+5.5) at Dallas Cowboys

The Redskins already poor pass defense could be in big trouble on Sunday night. Tony Romo is on track for the best season of his career, and he went toe-to-toe with Peyton Manning last week. Robert Griffin III says he feeling like his old self, but Washington’s offense isn’t good enough to keep up with Dallas.

Prediction ATS: Dallas

Indianapolis Colts (-1.5) at San Diego Chargers

The Chargers might be one of the toughest teams to figure out in the NFL. Philip Rivers is having a bounce-back season, but the team has remained inconsistent, losing to the likes of Oakland and Tennessee. Andrew Luck and the Colts are nothing but consistent, making them the best bet in San Diego.

Prediction ATS: Indianapolis