The Basel-based group has already cut thousands of jobs, shut several sites, notably in Britain. It has also shifted its focus to specialty medicines over the past year in a bid to boost profitability and protect its bottom line.
The latest measures, which affect 1.7 percent of Novartis' global workforce and involve moving more commoditized business activities to less expensive countries, should allow the group to rake in annual savings of more than $200 million.
Like its cross-town rival Roche
The two groups have stressed their commitment to investment in Switzerland, but they are both outsourcing routine manufacturing and other operations to cheaper countries.
Over the next three to five years, Novartis will close two sites in Switzerland and one in Italy.
It will scale back and outsource technical research and development, data management, clinical trial monitoring, drug safety and epidemiology and drug regulatory affairs in Switzerland and the United States.
Some research activity will be moved from Switzerland to the United States, and Novartis will create 700 new jobs in low cost countries, the group said.
The extra cost-saving measures were offset, however, by news that two lung drugs Novartis is developing with British partner Vectura
At 0933 GMT (5:33 a.m. EDT), Novartis shares were trading 2.6 percent weaker, underperforming a 0.5 percent lower European healthcare index <.SXDP> as its quarterly results also failed to impress.
Overall, third-quarter results were on the weaker side, but part of this was driven by FX (foreign exchange), Tim Anderson, an analyst at Bernstein, said.
Global drugmakers have cut tens of thousands of jobs ahead of patent expirations on their top-selling products, while a growing squeeze on medicine prices by cash-strapped governments is adding to the pressure to cut costs.
The vast sales forces for major drugs going off patent, such as Pfizer's
At some companies, research jobs, too, have been in the firing line, although Novartis says it remains committed to maintaining a world-class R&D operation.
Novartis Chief Executive Joe Jimenez warned on a conference call with journalists that pricing pressures were set to continue, adding he sees a negative impact of 5 percent in European pharma this year.
Jimenez also said it was the tough pricing environment rather than the strong franc that was behind the latest round of job cuts.
Novartis' announcement came as the group posted a 7 percent rise in its third quarter core earnings per share to $1.45, largely in line with expectations, boosted by solid demand for its newest products like multiple sclerosis pill Gilenya.
The group has one of the strongest pipelines in the industry, and this should help it to navigate patent losses on some of its key drugs, such as top-selling blood pressure medicine Diovan.
Novartis expects low double-digit sales growth in constant currencies for the group this year, while growth in its pharma unit is seen in the low- to mid-single digit range.
It has also forecast that its core operating margin in constant currencies should improve, but it said it expected to take a restructuring charge of around $300 million in the fourth quarter.
The robust franc dented Novartis' third-quarter core operating income margin which slipped 1.7 percentage points to 27.7 percent.
(Additional reporting by Ben Hirschler; Editing by Mike Nesbit)