The top after-market NASDAQ Stock Market gainers are: MannKind, Micromet, NVIDIA, Red Robin Gourmet Burgers, and United Online. The top after-market NASDAQ Stock Market losers are: Body Central, BMC Software, American Superconductor, Southwest Bancorp, and Premier Financial Bancorp.

Gainers

MannKind Corp. (MNKD) stock jumped 17.30 percent to $2.78 in the after-market trading. The company said it has confirmed with the U.S. Food and Drug Administration the design of two clinical studies that evaluate the efficacy and safety of AFREZZA (insulin human [rDNA origin]), an investigational, ultra rapid-acting mealtime insulin therapy, administered using MannKind’s next-generation inhaler. The FDA had previously requested that MannKind conduct two clinical trials with the next-generation inhaler (one in patients with type 1 diabetes and one in patients with type 2 diabetes), with at least one trial including a treatment group using the previously studied MedTone inhaler in order to obtain a head-to-head comparison of the pulmonary safety data for the two devices.

Study 171 is an open-label study in patients with type 1 diabetes. After a run-in period, during which all patients will be optimized on their basal insulin regimen, subjects will be randomized to one of three arms: a control arm, in which patients utilize injected rapid-acting insulin at mealtimes, or one of two AFREZZA arms, one each for the MedTone and next-generation device. After the mealtime insulin is titrated, there will be a 12-week observation period on stable doses of the mealtime insulin to assess HbA1c levels, which is the primary outcome parameter. Study 174 will assess AFREZZA using the next-generation inhaler in patients with type 2 diabetes who are inadequately controlled on metformin with or without a second or third oral medication. Patients will be randomized to treatment with AFREZZA or placebo in a randomized fashion. The study will have a titration period, followed by a 12-week observation period to assess HbA1c levels.

Micromet, Inc. (MITI) stock climbed 17.16 percent to $5.53 in the after-market trading.

NVIDIA Corp. (NVDA) stock advanced 11.86 percent to $15 in the after-market trading. Profit for the second quarter was $151.6 million or $0.25 per share, compared to a loss of $141.0 million or $0.25 per share last year. Adjusted earnings were $193.5 million or $0.32 per share, higher than last year's $47.6 million $0.08 per share. Revenue grew to $1.02 billion from $811.21 million. Analysts had expected profit of $0.25 per share on revenue of $1.01 billion. Looking ahead into the third quarter, the company expects revenue growth of 4 percent to 6 percent from last quarter and gross margin to be flat. The company expects third quarter operating expenses of $361 million to $366 million and adjusted operating expenses of $319 million to $321 million.

Red Robin Gourmet Burgers Inc. (RRGB) stock grew 10.13 percent to $37.28 in the after-market trading. Profit for the second quarter was $6.9 million or $0.44 per share, up from $4.3 million or $0.28 per share last year. Adjusted earnings were $7.5 million or $0.48 per share, up from $4.5 million or $0.29 per share last year. Revenue grew 7.2 percent to $215.80 million. Analysts had expected profit of $0.36 per share on revenue of $213.04 million. Same-restaurant sales increased 3.1 percent for company-owned restaurants on a 4.5 percent growth in average guest check, partially offset by a 1.4 percent decrease in guest counts.

United Online, Inc. (UNTD) stock gained 4.88 percent to $5.37 in the after-market trading.

Losers

Body Central Corp. (BODY) stock fell 7.68 percent to $19 in the after-market trading. Profit for the second quarter was $5.3 million or $0.33 per share, up from $2.3 million or $0.19 per share last year. Revenue grew 22.1 percent to $74.7 million. Analysts had expected profit of $0.30 per share on revenue of $73.34 million. Looking ahead into the third quarter, the company expects earnings of $0.14 to $0.16 per share and revenue of $64 million to $66 million, while Street predicts profit of $0.16 per share on revenue of $66.02 million. For the fiscal 2011, the company increased its earnings guidance to range of $1.14 to $1.19 per share from previous forecast of $1.12 to $1.16 per share. The company also raised its 2011 revenue outlook to range of $290 million to $294 million from previous range of $286 million to $292 million. Street predicts profit of $1.16 per share on revenue of $292.71 million.

BMC Software Inc. (BMC) stock slid 4.44 percent to $38.9778 in the after-market trading.

American Superconductor Corp. (AMSC) stock declined 3.86 percent to $5.98 in the after-market trading. The company said it reduced its global workforce by around 30 percent or 150 jobs following efforts to better align costs with its revenue expectations, which have been affected by business and contractual issues with AMSC's largest customer, Sinovel Wind Group Co., Ltd. After the job reductions, American Superconductor will have about 600 employees on its rolls worldwide. The reduction in workforce has also resulted in a cut of its annualized expenses by about $30 million since March 31, 2011. The company expects to report a significant net loss on revenue of less than $10 million for fiscal first quarter. The company also expects to incur restructuring charges of $3 million to $4 million for severance and related expenses in the second quarter.

Southwest Bancorp Inc. (OKSB) stock decreased 3.73 percent to $4.90 in the after-market trading.

Premier Financial Bancorp Inc. (PFBI) stock declined 3.62 percent to $6.65 in the after-market trading.