The top after-market NASDAQ gainers Wednesday were: Vivus, Orexigen Therapeutics, Arena Pharmaceuticals, Hansen Medical, Questcor Pharmaceuticals and Zix Corp. The top after-market NASDAQ losers were: Horizon Pharma, Smith Micro Software, GRAVITY Co, United Online and Achillion Pharmaceuticals.

Gainers:

Vivus, Inc. (VVUS) stock climbed 100.47 percent to $21.15 in aftermarket trading session. The company announced that the U.S. Food and Drug Administration Endocrinologic and Metabolic Drugs Advisory Committee recommended Qnexa be granted marketing approval by the FDA for the treatment of obesity in adults. The Committee voted 20 to 2, on the recommendation for an approval based on a favorable benefit-risk profile.

Orexigen Therapeutics, Inc. (OREX) stock climbed 19.94 percent to $3.85 in aftermarket trading session on news that VVUS’s weight-loss pill Qnexa won the backing of a U.S. advisory panel.

Arena Pharmaceuticals, Inc. (ARNA) stock climbed 18.78 percent to $2.15 in postmarket trading session on news that VVUS’s weight-loss pill Qnexa won the backing of a U.S. advisory panel.

Hansen Medical, Inc. (HNSN) stock surged 7.88 percent to $3.56 in post market trading session. Its fourth quarter net loss narrowed to $0.16 per share from $0.20 per share in the same quarter a year-ago.

Questcor Pharmaceuticals, Inc. (QCOR) stock surged 5.76 percent to $36.74 in aftermarket trading session. The company reported fourth quarter net profit of $31.64 million or $0.48 per share compared to $6.42 million or $0.10 per share in the same period a year-ago.

Zix Corp. (ZIXI) stock gained 4.91 percent to $2.99 in post market trading session. The company stock plunged more than 9 percent in regular trading session.

Losers:

Horizon Pharma, Inc. (HZNP) stock plunged 8.63 percent to $2.86 in post market trading session. The company announced that it has entered into a loan agreement with a group of lenders to provide $60 million in capital.

Smith Micro Software, Inc. (SMSI) stock plunged 7.33 percent to $2.15 in post market trading session.

GRAVITY Co., Ltd. (GRVY) stock declined 4.88 percent to $2.69 in aftermarket trading session.

United Online, Inc. (UNTD) stock declined 4.8 percent to $5.35 in aftermarket trading session. The company reported fourth quarter adjusted net income of $0.25 per share compared to $0.30 per share in the same quarter a year-ago.

Achillion Pharmaceuticals, Inc. (ACHN) stock fell 3.1 percent to $10.00 in post market trading session. The company stock declined more than 3 percent in regular trading session.

Prospect Capital Corp. (PSEC) stock declined 2.72 percent to $11.08 in aftermarket trading session. The company announced that it is offering 12,000,000 shares of its common stock pursuant to an effective shelf registration statement in an underwritten public offering.