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Neuralstem Reports Second Quarter Financial Results and Provides Business & Clinical Update

16 Aug, 2010 @ 05:31 pm EDT
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DIAGNOCURE INC. (CUR), Hospitals, Pharmaceutical, Maryland

ROCKVILLE, Md., Aug. 16 /PRNewswire-FirstCall/ -- Neuralstem, Inc. (NYSE Amex: CUR) today reported its financial results for the three months and six months periods ended June 30, 2010 and provided a business and clinical update.

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Richard Garr, Neuralstem's President & CEO, said, "2010 continues to be a year of major milestones for Neuralstem. We started by moving into the clinic to treat Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease) with our spinal cord neural stem cell therapy. We also completed the necessary financings to fund our transition from the laboratory into the clinic for multiple trials that we expect to start in the balance of the year. Towards that end, we expect to file an IND for a Phase I safety trial for chronic spinal cord injury with the FDA later this month. We also expect to file an IND for a Phase I safety trial for major depression for our small molecule drug in the fourth quarter."

Clinical Program and Business Highlights

In May 2010, Neuralstem's President & CEO, Richard Garr, presented at the Fifth Annual World Stem Cells and Regenerative Medicine Congress, in London, UK. Mr. Garr's presentation "Goals, Challenges and Solutions for Bringing Cell-Based ALS Therapy to the Clinic" addressed the goals and scientific potential of applying cell therapy to ALS, as well as the challenges and solutions in bringing this treatment to patients.

The company also announced that, after reviewing the safety data from the first cohort of 3 patients, the independent Safety Monitoring Board overseeing the ALS trial gave the approval to move to the second cohort of 3 patients, which took place over the third quarter. The first cohort of 3 patients received only 5 injections each, unilaterally. The second cohort of patients received 10 injections each, bilaterally, in the lower spinal cord. Subject to review of the first two cohorts and approval by the Safety Monitoring Board, the next part of the trial will move into earlier-stage ALS patients in October.

In June 2010, the Principal Investigator of Neuralstem's Phase I clinical trial to treat ALS with its spinal cord stem cells, Dr. Eva Feldman, presented at the inaugural A. Alfred Taubman Forum on Improving Science and Technology Innovation in the United States, at The Brookings Institution in Washington, D.C. Dr. Feldman, PhD, MD, is the Russell DeJong Professor of Neurology and Director of the ALS Clinic at the University of Michigan. Dr. Feldman's talk addressed the importance of medical research at academic centers to keep America at the forefront of innovation, of which the ALS trial is an example. As part of the talk, Dr. Feldman discussed some general aspects of the ALS trial.

In June 2010, Neuralstem completed a financing via a registered direct offering of $10 million of units to institutional investors and provided updates on its BioTherapeutics, BioPharmaceuticals and International initiatives:

BioTherapeutics: Neuralstem announced that it will submit a clinical trial application in chronic spinal cord injury to the FDA as the first of planned additional FDA clinical trial submissions utilizing the company's neural stem therapy platform. The company is on schedule to file an Investigational New Drug (IND) submission with the FDA this month. The Phase I clinical trial for chronic spinal cord injury is planned to be a multisite study.

BioPharmaceuticals: Four Neuralstem molecules have demonstrated neurogenic activity, the ability to stimulate neurogenesis of normal adult brain cells in the hippocampus. Neuralstem scientists have been developing this new class of drugs over the past 12 months. They are currently completing the pre-clinical pharmaceutical programs to submit INDs to the FDA for Phase I clinical trials for the company's first-in-class neurogenic small molecule drug. The first Phase I trial of Neuralstem's small molecule compound is expected by early 2011, with an initial trial indication of major depression. Neuralstem believes that its ability to screen against its proprietary cells provides a valuable and unique advantage for the discovery of novel compounds to central nervous system (CNS) diseases. As such, this first small molecule drug program will be a powerful validation of its screening platform.

International Initiatives: Neuralstem announced in June of 2010 that it commenced the formation of a wholly owned subsidiary, Neuralstem China (Suzhou Neuralstem Biopharmaceutical Company, Ltd.), with the intention of conducting stem cell clinical trials in the People's Republic of China. The company anticipates the formation to be completed during the third quarter of 2010 and operations to begin shortly thereafter. Additionally, the company continues to support its Korean partner, CJ Cheil Jedang Corporation, as it moves to launch its first Asian markets clinical trial. Neuralstem also continues to work on Huntington's disease with its collaborators at Albert-Ludwigs-University in Freiburg, Germany.

Second Quarter and Six Months Financial Results

During the second quarter ended June 30, 2010, Neuralstem received a total of $9.3 million from a registered direct placement. Cash, cash equivalents and short-term marketable securities at June 30, 2010 totaled approximately $14 million, compared with approximately $2.3 million at December 31, 2009.

The Company reported a second quarter 2010 net loss of $4.9 million or $0.12 per share, compared with a net loss of $3.2 million, or $0.09 per share a year ago. The change from 2009 to 2010 was primarily due to increased research spending related to the clinical trials which began in January 2010, and to the costs of completing preclinical trial studies for new indications. Net loss attributable to common stockholders for the first six months of 2010 was $11,718,301, or $0.29 per share, compared with $2,283,769, or $0.07 per share for the comparable period in 2009. The increase was primarily attributable to increases in R&D and legal fees, and non-cash stock-based compensation expense, offset by a non-cash gain related to our warrant accounting for the first quarter 2009.

For the six months ended June 30, 2010, cash used in operating activities totaled $4,878,730, an increase of $2,350,454 compared to the same period in the prior year, primarily attributable to increased research spending related to the beginning of clinical trials, the costs of completing preclinical trial studies for new indications, and increased legal fees.

About Neuralstem

Neuralstem's patented technology enables the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells constitutively into mature, physiologically relevant human neurons and glia. Neuralstem is in a Phase I safety clinical trial for Amyotrophic Lateral Sclerosis (ALS), often referred to as Lou Gehrig's disease. The company is also targeting major central nervous system diseases in addition to ALS, including traumatic spinal cord injury, ischemic spastic paraplegia, and Huntington's disease.

Through its proprietary screening technology, Neuralstem has discovered and patented compounds that may stimulate the brain's capacity to generate new neurons, possibly reversing the pathologies of some central nervous system conditions. The company plans to initiate clinical trials to treat Alzheimer's disease and major depression with its lead compound, as well as pursue additional indications, including traumatic brain injury, post traumatic stress syndrome, stroke and schizophrenia.

For more information, please go to www.neuralstem.com

Cautionary Statement Regarding Forward Looking Information

This news release may contain forward-looking statements made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. Investors are cautioned that such forward-looking statements in this press release regarding potential applications of Neuralstem's technologies constitute forward-looking statements that involve risks and uncertainties, including, without limitation, risks inherent in the development and commercialization of potential products, uncertainty of clinical trial results or regulatory approvals or clearances, need for future capital, dependence upon collaborators and maintenance of our intellectual property rights. Actual results may differ materially from the results anticipated in these forward- looking statements. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in Neuralstem's periodic reports, including the annual report on Form 10-K for the year ended December 31, 2009, and in its quarterly report on Form 10-Q for the period ended June 30, 2010. 


               Neuralstem, Inc.

                Balance Sheets


                                                  December
                               June 30,              31,
                                      2010              2009
                              (Unaudited)
                              -----------

           ASSETS
    CURRENT ASSETS
    Cash and cash
     equivalents               $14,025,745        $2,309,774
    Prepaid expenses               272,613           143,600

    Total current
     assets                     14,298,358         2,453,374
                                ----------         ---------

    Property and
     equipment, net                187,113           196,755
    Intangible assets,
     net                           370,421           301,560
    Other assets                    49,409            55,716

    Total assets               $14,905,301        $3,007,405
                               ===========        ==========


      LIABILITIES AND
        STOCKHOLDERS'
      EQUITY (DEFICIT)

    CURRENT LIABILITIES

    Accounts payable
     and accrued
     expenses                   $1,144,916          $791,607
    Accrued bonus
     expense                       588,338           769,215
    Fair value of
     warrant
     obligations                 2,189,064                 -
                                 ---------               ---

    Total current
     liabilities                 3,922,318         1,560,822
                                 ---------         ---------

    LONG-TERM
     LIABILITIES

    Fair value of
     warrant
     obligations                         -         6,462,039

    Total liabilities            3,922,318         8,022,861
                                 ---------         ---------

    STOCKHOLDERS'
     EQUITY (DEFICIT)

    Preferred stock,
     7,000,000 shares
     authorized, zero
     shares                              -                 -
      issued and
       outstanding
    Common stock, $0.01
     par value; 150
     million shares                460,080           357,438
      authorized,
       46,008,024 and
       35,743,831 shares
       outstanding
      in 2010 and 2009
       respectively
    Additional paid-in
     capital                    89,808,035        62,193,937
    Accumulated deficit        (79,285,132)      (67,566,831)
                               -----------       -----------
    Total stockholders'
     equity (deficit)           10,982,983        (5,015,456)
                                ----------        ----------

    Total liabilities
     and stockholders'
     equity (deficit)          $14,905,301        $3,007,405
                               ===========        ==========





                    Neuralstem, Inc.

                Statements of Operations
                       (Unaudited)


                            Three Months                Six Months
                           Ended June 30,             Ended June 30,
                             2010          2009           2010          2009
                             ----          ----           ----          ----

    Revenues                   $-            $-             $-            $-

    Operating
     expenses:
    Research and
     development
     costs              2,613,676     1,452,793      4,513,640     2,886,802
    General,
     selling and
     administrative
     expenses           1,550,814     1,249,947      3,238,649     2,707,186
    Depreciation
     and
     amortization          30,601        21,424         59,663        42,220
                           ------        ------         ------        ------
                        4,195,091     2,724,164      7,811,952     5,636,208
                        ---------     ---------      ---------     ---------
    Operating
     loss              (4,195,091)   (2,724,164)    (7,811,952)   (5,636,208)
                       ----------    ----------     ----------    ----------

    Nonoperating
     (expense)
     income:
    Interest
     income                 9,653         8,516         15,463        10,780
    Interest
     expense               (1,462)            -         (2,120)            -
    Warrant
     issuance
     and
     modification
     expense                    -             -     (1,906,800)            -
    (Loss) gain
     from change
     in fair
     value of
     warrant
     obligations         (764,440)     (473,799)    (2,012,892)    3,341,659
                         --------      --------     ----------     ---------
                         (756,249)     (465,283)    (3,906,349)    3,352,439
                         --------      --------     ----------     ---------

    Net loss
     attributable
     to common
     shareholders     $(4,951,340)  $(3,189,447)  $(11,718,301)  $(2,283,769)
                      ===========   ===========   ============   ===========

    Net loss per
     share -
     basic and
     diluted               $(0.12)       $(0.09)        $(0.29)       $(0.07)
                           ======        ======         ======        ======

    Weighted
     average
     common
     shares
     outstanding
     - basic and
     diluted           42,450,338    33,760,091     40,505,586    33,755,720
                       ==========    ==========     ==========    ==========

SOURCE Neuralstem, Inc.

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