Nomura Holdings, Sodastream International, General Motors, BioMarin Pharmaceutical, SAP AG, Rigel Pharmaceuticals, AIXTRON SE, Portland General Electric, Carnival Corp and Amarin Corp are among the companies whose shares are moving in pre-market trading on Tuesday.

Gainers

Nomura Holdings Inc. (NYSE:NMR) stock surged 6.08 percent to $7.68 in pre-market trading. The company stock has a 52-week low of $3.05, a 52-week high of $9.64 and $26.87 billion in market capitalization.

Sodastream International Ltd. (NASDAQ:SODA) stock gained 4.03 percent to $71.84 in pre-market trading. The company stock surged more than 8 percent in regular trading on Friday.

General Motors Co. (NYSE:GM) stock advanced 2.82 percent to $35.39 in pre-market trading. The company stock has a 52-week low of $18.72, a 52-week high of $34.91 and $47.32 billion in market capitalization.

BioMarin Pharmaceutical Inc. (NASDAQ:BMRN) stock advanced 2.04 percent to $61.00 in pre-market trading. The company stock has a 52-week low of $34.30, a 52-week high of $71.56 and $8.30 billion in market capitalization.

SAP AG (NYSE:SAP) stock gained 1.54 percent to $76.01 in pre-market trading. The company stock has a 52-week low of $54.78, a 52-week high of $84.66 and $89.25 billion in market capitalization.

Losers

Rigel Pharmaceuticals Inc. (NASDAQ:RIGL) stock plunged 6.84 percent to $4.22 in pre-market trading. Rigel Pharma and AstraZeneca announced the results from OSKIRA-2 and OSKIRA-3, the remaining pivotal Phase 3 clinical trials investigating fostamatinib, a rheumatoid arthritis pill. Following disappointing overall results, AstraZeneca said it has decided not to proceed with regulatory filings for fostamatinib and will return the rights to the compound to Rigel.

AIXTRON SE (NASDAQ:AIXG) stock declined 3.03 percent to $17.27 in pre-market trading. The stock has a 52-week low of $11.21, a 52-week high of $18.06 and $1.80 billion in market capitalization.

Portland General Electric Co. (NYSE:POR) stock fell 2.38 percent to $29.99 in pre-market trading. Currently, the company expects fiscal 2013 net profit to be in a range of $1.35 to $1.50 a share, down from its prior estimation of $1.85 to $2.00 a share, below Reuters' forecast of a profit of $1.92 a share.

Carnival Corp. (NYSE:CCL) stock declined 1.50 percent to $32.17 in pre-market trading. The stock has a 52-week low of $30.65, a 52-week high of $39.95 and $26.37 billion in market capitalization.

Amarin Corp PLC. (NASDAQ:AMRN) stock fell 1.43 percent to $6.90 in pre-market trading. The stock has a 52-week low of $6.25, a 52-week high of $15.96 and $1.05 billion in market capitalization.