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 Shares of Salesforce.com jumped nearly 9 percent Wednesday.  Salesforce

Pluristem Therapeutics, Salesforce.com, Lloyds Banking Group, Delhaize Group, NRG Energy, Neurometrix, Toyota Motor, US Airways Group and Joy Global Inc. are among the companies whose shares are moving in the pre-market trading on Wednesday.

Gainers

Pluristem Therapeutics Inc. (NASDAQ:PSTI) stock surged 8.04 percent to $3.09 in pre-market trading. The company stock slumped more than 14 percent in regular trading on Tuesday after Pluristem announced that a mid-stage trial of its experimental muscle pain drug was put on clinical hold by the U.S. Food and Drug Administration (FDA) after a patient had a serious allergic reaction requiring hospitalization.

Salesforce.com Inc. (NYSE:CRM) stock gained 1.80 percent to $38.48 in pre-market trading. Salesforce.com stock plunged nearly 8 percent in regular trading on Tuesday after the company announced that it has agreed to buy ExactTarget (NYSE:ET) in a transaction valued at approximately $2.5 billion.

Lloyds Banking Group Plc (NYSE:LYG) stock advanced 1.59 percent to $3.84 in pre-market trading. The company stock has a 52-week low of $1.54, a 52-week high of $3.85 and $67.28 billion in market capitalization.

Delhaize Group (NYSE:DEG) stock advanced 1.27 percent to $65.20 in pre-market trading. The company stock has a 52-week low of $32.11, a 52-week high of $65.93 and $6.50 billion in market capitalization.

Losers

NRG Energy Inc. (NYSE:NRG) stock plunged 5.92 percent to $23.70 in pre-market trading. The company stock has a 52-week low of $14.65, a 52-week high of $28.67 and $8.12 billion in market capitalization.

Neurometrix Inc. (NASDAQ:NURO) stock fell 4.62 percent to $2.48 in pre-market trading. The company announced on Tuesday that it entered into a definitive securities purchase agreement with a single institutional investor providing for the issuance of $5 million worth of shares of Series A-1 and Series A-2 convertible preferred stock and five year warrants to purchase up to 2.38 million shares of common stock at an exercise price of $2.00 per share.

Toyota Motor Corp. (NYSE:TM) stock declined 2.33 percent to $115.50 in pre-market trading. The company stock has a 52-week low of $72.04, a 52-week high of $130.99 and $187.29 billion in market capitalization.

US Airways Group Inc. (NYSE:LCC) stock fell 1.42 percent to $17.40 in pre-market trading. The company stock has a 52-week low of $9.74, a 52-week high of $19.70 and $2.89 billion in market capitalization.

Joy Global Inc. (NYSE:JOY) stock declined 1.11 percent to $53.45 in pre-market trading. The company stock has a 52-week low of $47.69, a 52-week high of $69.16 and $5.74 billion in market capitalization.