The top pre-market NASDAQ stock market gainers are: ARIAD Pharmaceuticals, Datalink, Sterling Bancshares, China XD Plastics and Ku6 Media. The top pre-market NASDAQ stock market losers are: Apple, Avago Technologies, Cypress Semiconductor, NVIDIA and ASML Holdings.

Gainers

ARIAD Pharmaceuticals, Inc. (NASDAQ:ARIA) shares surged 36.19 percent to $7.15 in pre-market trading hours. The company announced that ridaforolimus, an investigational oral mTOR inhibitor, met the primary endpoint of improved progression-free survival compared to placebo in the Phase 3 Succees trial conducted in patients with metastatic soft-tissue or bone sarcomas who previously had a favorable response to chemotherapy.

Datalink Corp. (NASDAQ:DTLK) shares advanced 31.28 percent to $5.96 in pre-market trading session. The company raised its fourth quarter guidance and said it expects GAAP earnings per share in the range of $0.15 per share - $0.18 per share compared to previous target of $0.09 per share - $0.13 per share range.

Sterling Bancshares, Inc. (NASDAQ:SBIB) shares surged 20.78 percent to $9.30 in pre-market trading session on news that Comerica Inc. (CMA) will acquire all of the outstanding shares of common stock of Sterling in a stock-for-stock transaction to accelerate its growth in Texas.

Under terms of the agreement, each outstanding share of Sterling common stock will be exchanged for 0.2365 shares of Comerica common stock. The deal values each share of Sterling at $10.00, based on Comerica's 15-day average closing share price through January 11 of $42.28 on the NYSE.

China XD Plastics Co Ltd. (NASDAQ:CXDC) shares advanced 10.51 percent to $6.10 in pre-market trading session.

Ku6 Media Co., Ltd. (NASDAQ:KUTV) shares advanced 6.74 percent to $5.07 in pre-market trading session. The stock has a 52 week low of $2.22 and 52 week high of $8.40 and has $151.75M market capitalization.

Losers

Apple Inc. (NASDAQ:AAPL) shares declined 4.63 percent to $332.35 in premarket trading hours on Tuesday after it was reported that Chairman Steve Jobs would take another leave of absence, fuelling worries about the potential length of his absence and the extent of his health issues.

The company is set to release its first quarter earnings on Tuesday after the market closes. Analysts are expecting Apple to earn $5.39 per share compared to $3.67 per share in the same quarter last year.

Avago Technologies Ltd. (NASDAQ:AVGO) shares declined 4.52 percent to $27.70 in pre-market trading session. The company announced sale of 25,000,000 ordinary shares by certain existing shareholders to Deutsche Bank Securities and Barclays Capital, as underwriters in the registered public offering of those shares.

Cypress Semiconductor Corp. (NASDAQ:CY) shares declined 1.78 percent to $20.96 in pre-market trading session. The stock has a 52 week low of $9.73 and 52 week high of $21.71 and has 165.85M outstanding shares.

NVIDIA Corp (NASDAQ:NVDA) shares declined 1.74 percent to $23.18 in pre-market trading session. The stock has a 52 week low of $8.65 and 52 week high of $23.98 and has 581.00M outstanding shares.

ASML Holding N.V. (NASDAQ:ASML) shares declined 1.37 percent to $40.27 in pre-market trading session.