The top pre-market NASDAQ Stock Market gainers are: Vermillion, Yahoo, Randgold Resources, Power-One, and S1 Corp. The top pre-market NASDAQ Stock Market losers are: Sangamo Biosciences, Melco Crown Entertainment, Vitesse Semiconductor, Wynn Resorts, and Green Mountain Coffee Roasters.

Gainers

Vermillion, Inc. (VRML) stock jumped 18.77 percent to $3.10 in the pre-market trading. The company announced positive top-line results from the intended use study for its peripheral artery disease (PAD) blood test, VASCLIR. The goals of the study were to validate the markers described in earlier publications (Circulation, 2007 and Vascular Medicine, 2008) and to develop and validate a biomarker panel applicable to the intended use population. The intended use study was a prospective, double-blinded multi-center study of approximately 1,000 subjects who met specific inclusion criteria for being at increased risk of having PAD, including smokers and diabetics age 50 or above and elderly age 70 or above.

Yahoo Inc. (YHOO) stock gained 4.10 percent to $13.71 in the pre-market trading. Jack Ma, the Chief Executive officer of Alibaba Group Holding Ltd., expressed his interested in acquiring Yahoo and has held discussions with other potential buyers on possible deal, according to media reports. Alibaba Group joins private equity firms such as Silver Lake and media executive Peter Chernin as possible suitors for Yahoo, the reports say. Meanwhile, Yahoo's board is putting a higher priority on evaluating a potential sale of all or parts of the Internet Company over its search for a new CEO.

Randgold Resources Ltd. (GOLD) stock increased 3.34 percent to $99.95 in the pre-market trading.

Power-One Inc. (PWER) stock gained 2.22 percent to $4.60 in the pre-market trading.

S1 Corp. (SONE) stock rose 1.96 percent to $9.35 in the pre-market trading. ACI Worldwide Inc. (ACIW) has agreed to buy S1 for about $360 million in cash and 5.8 million ACI shares. S1 stockholders can elect to receive $10.00 in cash or 0.3148 shares of ACI stock for each S1 share they own, subject to proration, such that in the aggregate 33.8 percent of S1 shares are exchanged for ACI shares and 66.2 percent are exchanged for cash. Further, ACI and S1 reiterated the respective guidance each had previously provided, excluding the impact of the transaction, for 2011. ACI will update its guidance to include the acquisition of S1 following the completion of the transaction.

Losers

Sangamo Biosciences Inc. (SGMO) stock plunged 29.20 percent to $3.08 in the pre-market trading. The company said its Phase 2b study of SB-509-901 did not meet its primary or secondary clinical endpoints in subjects with moderate severity diabetic neuropathy as compared to placebo. The double blind, repeat-dosing, placebo controlled Phase 2b study, SB-509-901, was designed to finalize dose, schedule, and primary and secondary endpoints for pivotal Phase 3 trials. SB-509 treatment did not show statistically significant improvements from baseline compared with placebo at 180 days in the primary endpoint, sural nerve conduction velocity, the secondary endpoint, neuropathy impairment score in the lower limb, or intraepidermal nerve fiber density.

Melco Crown Entertainment Ltd. (MPEL) stock fell 9.15 percent to $7.55 in the pre-market trading.

Vitesse Semiconductor Corp. (VTSS) stock tumbled 5.08 percent to $2.80 in the pre-market trading. The company lowered its fourth quarter revenue outlook to range of $29 million to $30.5 million from previous forecast of $35 million to $38 million, while Street predicts $35.75 million. The company said it reduced its revenue guidance due to a continued softening of global demand and also a delayed intellectual property contract. Vitesse lifted its fourth quarter operating expenses forecast to range of $24.1 million to $24.7 million from previous outlook range of $21.5 million and $23.0 million.

Wynn Resorts Ltd. (WYNN) stock declined 3.98 percent to $110.50 in the pre-market trading.

Green Mountain Coffee Roasters Inc. (GMCR) stock decreased 3.44 percent to $89.74 in the pre-market trading.