Press Release

ImmuneRegen(R) Appoints Wound Healing and Tissue Regeneration Expert Spencer A. Brown, Ph.D. to Advisory Board

Company Gains Further Scientific and Biotech Business Expertise to Accelerate Development of, and the Opportunity for Clinical Trials for, New Wound Care Drug
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Posted 01 December 2008 @ 06:30 am ET

SCOTTSDALE, AZ -- (Marketwire) -- 12/01/08 -- ImmuneRegen® BioSciences, Inc., awholly owned subsidiary of IR BioSciences Holdings, Inc. (OTCBB: IRBS),announced today that it appointed Spencer A. Brown, Ph.D., to its advisoryboard. Dr. Brown, who has more than 20 years experience as a clinicalresearcher and biotech company entrepreneur and advisor, is director ofresearch of the plastic surgery department at the University of Texas Southwestern MedicalCenter (UTSW). He specializes in wound care, tissue regeneration andreconstructive surgery research.

"We are delighted Dr. Brown is joining our advisory board. He not onlybrings his extensive wound healing research that includes preclinical andclinical studies in stem cells, dermatology, reconstructive surgery andwound healing mechanisms, but also an understanding of the needs of biotechcompanies. His strategic counsel will be invaluable to our long-term growthand success," said Michael K. Wilhelm, ImmuneRegen president and CEO.

ImmuneRegen's drug candidate, Homspera®, is an adult stem cell activecompound that has been shown to regenerate and strengthen the immune systemand enhance wound healing. Dr. Brown and his research team at UTSW willperform additional research necessary to support ImmuneRegen's IND(Investigational New Drug) filing in an effort to obtain U.S. Food and DrugAdministration clearance to initiate human wound healing studies. UTSW alsowill conduct studies to confirm Homspera's efficacy for additional skinapplications.

"I am looking forward to working with ImmuneRegen's scientists and seniormanagement to advance the promise Homspera has demonstrated in enhancingtreatment and healing of wounds," Dr. Brown said. "I welcome theopportunity to work with a company that shows such promise."

Before joining Dallas-based UTSW as the director of research for thedepartment of plastic surgery in 2000, Dr. Brown was professor facultymember at Duke University Medical Center, Durham, N.C. Previously, Dr.Brown was research instructor and research assistant professor at BaylorCollege of Medicine in Houston.

He is a member of the National Institutes of Health's Special EmphasisBoard Study Section I K08 and Special Emphasis Board Study Section II, andUTSW's Institutional Board for Responsible Care for Human Subjects andInstitutional Animal Care and Use Committee (IACUC). He has served onnumerous society committee and reviewer for several journals.

Dr. Brown received his Bachelor of Arts degree from Gettysburg College andPh.D. degree from the University of Pennsylvania, with a thesis oncholesterol metabolism. He completed a postdoctoral fellowship at theSection of Atherosclerosis and Lipid Metabolism at the Baylor College ofMedicine. He has authored and co-authored more than 80 peer-reviewedarticles and presented more than 60 abstracts at national meetings,including the Plastic Surgery Research Council, Wound Healing Society andAmerican Society for Laser Medicine and Surgery.

About ImmuneRegen BioSciences, Inc.

ImmuneRegen BioSciences, Inc., a wholly owned subsidiary of IR BioSciencesHoldings, Inc. (OTCBB: IRBS), is a development-stage biotechnology companyfocused on the research, development and licensing of Homspera® and itsderivatives. Homspera is an adult stem cell active compound that, in studyresults, has been shown that it may have effects on the regeneration andstrengthening of the immune system and on enhancing wound healing. Toadvance its mission, the Scottsdale, Arizona-based company has forgednumerous study partnerships with industry and academic leaders, includingCelgene Cellular Therapeutics, HemoGenix, Lovelace Respiratory ResearchInstitute and Virion Systems, Inc. For more information, please visitwww.immuneregen.com.

Statements about ImmuneRegen's future expectations, including statementsabout the potential use and scientific results for ImmuneRegen's drugcandidates, science and technology, and all other statements in this pressrelease other than historical facts, are "forward-looking statements"within the meaning of Section 27A of the Securities Act of 1933, Section21E of the Securities Exchange Act of 1934, and as that term is defined inthe Private Securities Litigation Reform Act of 1995. ImmuneRegen intendsthat such forward-looking statements be subject to the safe harbors createdthereby. These future events may not occur as and when expected, if at all,and, together with ImmuneRegen's business, are subject to various risks anduncertainties. ImmuneRegen's actual results could differ materially fromexpected results as a result of a number of factors, including thelikelihood that FDA approval is obtained to initiate human wound healingstudies, the uncertainties inherent in research and developmentcollaborations, pre-clinical and clinical trials and product developmentprograms (including, but not limited to the fact that future results orresearch and development efforts may prove less encouraging than currentresults or cause side effects not observed in current pre-clinical trials),the evaluation of potential opportunities, the level of corporateexpenditures and monies available for further studies, capital marketconditions, and others set forth in ImmuneRegen's periodic report on Form10-Q for the three months ended September 30, 2008 as filed on November 13,2008, and on Form 10-KSB for the year ended December 31, 2007 as filed onMarch 31, 2008 and as amended on Form 10-KSB/A, Amendment No. 1 filed onSeptember 25, 2008 with the Securities and Exchange Commission. There areno guarantees that any of ImmuneRegen's proposed products will prove to becommercially successful. ImmuneRegen undertakes no duty to updateforward-looking statements.

CONTACT:Amendola Communications for ImmuneRegen480-664-8412Jan Shulman, ext. 12Email ContactJodi Amendola, ext 11Email Contact


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