With every member of tennis’ “Big 4” advancing to the quarterfinals of the 2015 French Open, Roger Federer will be the first one that looks to make his way into the semifinals. He’ll take on fellow Swiss Stan Wawrinka on Tuesday at Roland Garros.

Having faced each other 18 times in their careers, Federer has won nearly every match. But even though the No.2 player in the world is 16-2 against Wawrinka, the familiarity between them could make for a very competitive match.

"Mentally, it's a little bit bizarre to play one another," Federer said after winning to set up a match with Wawrinka. “We know exactly the zones that we want to hit, so we have to play slightly different to the traditional game plan."

Federer and Wawrinka have met one time in 2015. Much like in most of their head-to-head meetings, Wawrinka fell short in the semifinals of the ATP World Tour Masters 1000 Rome, suffering a 6-4, 6-2 loss. While that loss for Wawrinka came on clay, his two career victories against Federer have also come on clay. Federer last fell to Wawrinka at Monte Carlo last year 4-6, 7-6 (5), 6-2.

When the countrymen met at the 2014 Barclays ATP World Tour Finals in 2014, Federer needed a late comeback to beat Wawrinka. The one-time French Open champ knows he could be in for another tough matchup on Tuesday.

"We know each other very well. Most of the time it's a physical game, and we know that. So we are confident in our physical form," Federer said.

Neither player has had much trouble getting to the quarterfinals. Federer defeated Gael Monfils 6-3 4-6 6-4 6-1 in a match that was suspended on Sunday and completed on Monday. Wawrinka hasn’t lost a set in his last two matches, topping Gilles Simon 6-1 6-4 6-2 on Sunday.

"It was perfect," said Wawrinka. "I'm really happy to have won the match. I was expecting a tough match. It's never easy to play Gilles, especially in Grand Slams. I played really well, really aggressive."

The winner of the match won’t have to worry about Novak Djokovic, Rafael Nadal or Andy Murray until the finals. Federer or Wawrinka will go on to face Kei Nishikori or Jo-Wilfried Tsonga in the semifinals.

Federer is a -230 favorite at Bovada.lv. Wawrinka has been given +190 betting odds to pull off the upset.

Start Time: Shortly after 10 a.m. ET

TV Channel: Tennis Channel until 1 p.m. ET when coverage shifts to ESPN2

Online Stream: Tennis Channel Everywhere or WatchESPN