Clarence Clemons, a saxophonist for Bruce Springsteen’s E Street Band, died June 18 following a stroke. He was 69.

He died at his home on Saturday night, according to the Associated Press. He was hospitalized last week after a stroke.

In a statement, Springsteen said his loss was “immeasurable” and that he and his band mates were honored to have stood beside Clemons for nearly four decades, according to the Guardian.

He was known as the “Big Man” because of his 6 foot 5 inch frame and stage presence. He had been previously called the “soul” of the band, according to the report.

U2’s Bono spoke about Clemons Saturday night at Anaheim Angels Stadium during a concert before playing ‘Moment of Surrender’ in an encore, according to NME.

On Twitter, musicians who paid their respects included Bryan Adams and Public Enemy member Chuck D, who Tweeted: ‘RIP Big Clarence.’