The last time these two teams met was back in 2009 in a World Cup qualifier. The result? A one-sided 4-0 smackdown by Brazil. This rivalry is full of history and fierce passion and on Wednesday, South American pride is on the line in what is sure to be a physical affair. Let's take a closer look at where some of the value might lie.
For Brazil, Paulinho is set to return in the midfield after taking some time to rest up and heal his ankle injury. David Luiz suffered a broken nose against Mexico and a bruised leg vs Italy, but he's fit and ready to play.
Uruguay get their captain, Diego Lugano, back after a one game suspension. Defender Andres Scotti is not as lucky as he will serve his own suspension after getting sent off vs Tahiti.
Neymar, Neymar, Neymar?
Neymar entered this tournament with a lot of expectations, but he also came with a bit of baggage as there are many Brazilian fans who aren't enamoured with his attitude. Does three goals in three games on home soil change that perception?