The hosts Madrid are in 3rd place with 37 points while visitors are in 7th place with 30 points.
This is the first game in a triple header between the sides, as after this game the two sides meet each other in La Liga, before meeting again for the second leg next week.
Real Madrid continued to underwhelm as they achieved a disappointing draw away to Osasuna. It was a dreadful game with few chances from either side, and Madrid didn't manage their first effort on goal until the 90th minute. Although they had several key players missing, the feeling was they'd have enough to put away a poor Osasuna side.
Cristiano Ronaldo was suspended for that game but returns here and will give the team a much needed shot in the arm. Of the 11 knock-out ties that both teams have played in the competition, Madrid at home have won six out of the four games. Marcelo could make an appearance after injury, while Fábio Coentrão is also ready.
Valencia meanwhile continued their steady progress under new Coach Ernesto Valverde with a solid win over Sevilla. Although not spectacular, it showed once again this new gritty, determined and focused side to Valencia. The errors are being cut out of their game and they once again look genuine opposition.
These three games against Madrid will be a severe test for Valverde and Valencia though. Captain David Albelda will miss out due to injury, and he'll also miss the other two games. Fernando Gago and Sergio Canales are training well but this game could be too soon. Sofiane Feghouli is on AFCON duty.
At Half-time, two results stand out here, and that's the Draw/Draw at 9/1 with Bet Victor as well as the tempting Draw/Madrid at 7/2 with Coral. It's also worth a look at Madrid/Madrid as an early goal could see Jose Mourinho's team keep Valencia at arms lengths. That's priced at 8/11 with Coral.
Finally, we move to the First Goalscorer. Cristiano Ronaldo will return after his absence at the weekend, and so often he steps up for his team. The Portuguese is 11/5 with Paddy Power here to open the scoring. Elsewhere look to Karim Benzema at 7/2 with the same company. For Valencia, Roberto Soldado bagged a brace at the weekend and is in fine form. The Spanish striker is 9/1 with Ladbrokes. Alongside him is expected to be Jonas, the man who scored when the teams met earlier in the season. He is 12/1 with Ladbrokes here.
When To Watch
The game kicks off at 20:00 GMT and will be shown live on Sky Sports 1 HD
Real Madrid 2-1 Valencia
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Where To Watch Online: Real Madrid vs. Valencia