Arsene Wenger looks set to rotate his squad from the team that overcame Sunderlan in a 1-0 win last Saturday, as he appears intent upon resting some of his key players ahead of their Champions League clash with Bayern Munich on Tuesday.
Ignasi Miquel, having come on as a late substitute in the win against the Black Cats, looks set to deputize at center back, as Thomas Vermaelen (ankle) and Laurent Koscielnt (calf) continue to struggle with injury.
There are further repercussions from their exertions against Sunderland as Jack Wilshere's dead leg in that tie rules him out of this FA Cup clash. Carl Jenkinson is also ruled out with suspension after his red card in the same game.
Theo Walcott, Aaron Ramsey, Santi Cazorla and Oliver Giroud are also likely to be rested from the team that started the Sunderland game, with Abou Diaby, Gervinho, Alex Oxlade-Chamberlain, Tomas Rosicky and Lukas Podolski coming in, as their manager clearly has one eye on their Champions League game in midweek.
Blackburn, meanwhile, will look to play a full-strength side as manager Michael Appleton appears ready to keep faith in the team that earned a hard-fought 1-1 draw against Brighton last Saturday.
The one change that is likely to be made, however, comes in the form of the experienced Morten Gamst-Pedersen replacing DJ Campbell, with Colin Kazim-Richards assuming a role alongside the free-scoring Jordan Rhodes upfront.
Jake Kean, meanwhile, looks set to keep his place in goal as former England international Paul Robinson remains out-of-favor with new boss Appleton.
Blackburn Rovers: D/L/D/W/W/D
Arsenal: Szczesny (GK); Sagna, Mertesacker, Miquel, Monreal; Arteta, Diaby; Gervinho, Rosicky, Oxlade-Chamberlain; Podolski
Blackburn Rovers: Kean (GK); Orr, Dann, Hanley, Olsson; Pedersen, Murphy, Lowe, Olsson; Kazim-Richards, Rhodes
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Stadium: Emirates Stadium (Arsenal)
Date: Saturday, February 16th
Prediction: Arsenal 4-1 Blackburn Rovers