The Red Devils have been lackluster this season so far and Alex Ferguson would be hoping that they could finally get their season running with a big win over the Latics.
However, Fergie will have a tough time selecting his starting eleven due to the mounting injury crisis in the team.
Robin van Persie and Shinji Kagawa are unlikely to feature in the crunch game as the duo picked up minor injuries during their respective international matches. Wayne Rooney Phil Jones, Ashley Young and Chris Smalling are all sidelined, meaning a relatively weaker United team could be up against their 'weak' opponents.
On the other hand, Roberto Martinez could be able to play arguably his best possible team. Antolin Alcaraz has returned from suspension and James McArthur will be fit to play and hence, one can surely expect Wigan to return home with at least one point from the Theatre of Dreams.
Player to Watch Out For: Antonio Valencia
In the absence of van Persie, Rooney and Kagawa, Antonio Valencia will have to be at his very best to ensure a United win. The Ecuadorian hasn't quite lived up to his potential in the first three games, but his performances have not been poor either. Against a three man defense, who could in fact easily leak in goals, Valencia could have a devastating impact on the game and possibly provide numerous assists for the likes of Danny Welbeck and Javier Hernandez, who are likely to lead United's attack.
Manchester United: De Gea; Rafael, Ferdinand, Vidic, Evra; Valencia, Carrick, Cleverley, Giggs; Hernandez, Welbeck
Wigan: Al-Habsi;Alcaraz, Caldwell, Ramis; Boyce, McCarthy, McArthur, Maloney, Figueroa;
Kone, Di Santo
Prediction: Manchester United 1-0 Wigan
Manchester United should be able to squeeze past Wigan, but not without a hard struggle.
Even though the Latics have the capability to trouble Untied this time around, I don't quite see United losing at home to a team who has just one time at Old Trafford in seven league appearances.
Fun Fact: The Latics have had three players sent off in their last two visits to Old Trafford.
Note: Stats via Goal.com