The Miami Dolphins face a tough start under new head coach Joe Philbin, in the form of a road trip to face the Houston Texans.
The Dolphins must try and combat a fearsome pass rush with a rookie quarterback and a lack of quality at wide receiver.
Here are the three keys to the game and a prediction of the winner:
The Texans must blitz rookie QB Ryan Tannehill
That won't be a problem for Texans defensive coordinator Wade Phillips, who often blitzes five or six members of his front seven.
The Houston defense can rely on rush ends Connor Barwin, Whitney Mercilus and Brooks Reed. Combine that trio with a line led by J.J. Watt and the Texans pass rush will likely be too much for Dolphins rookie passer Ryan Tannehill.
The ex-Texas A&M star won the job in preseason, despite many believing he was a reach as the eighth overall pick in the 2012 draft. How he responds to heavy pressure will determine not only this game, but the Dolphins season.
The Dolphins must establish the running game with Reggie Bush
Featuring Reggie Bush is the Dolphins best hope to move the ball. The former New Orleans Saints all-rounder, proved he can be a workhorse back, by posting 1,086 yards on the ground in 2011.
He still has the speed and elusiveness to create big plays. Establishing the run can keep the ball away from the high-powered Texans offense.
Texans LT Duane Brown has to keep Cameron Wake at bay
Cameron Wake is the Dolphins best defensive play. If the prolific pass-rusher can get the better of Houston left tackle Duane Brown, Wake can cause havoc for the Texans' offense.
Brown is a skilled, agile and accomplished blocker. The 6'4", 320-pounder must use his technique and size to keep the quicker Wake at bay.
Prediction: Miami Dolphins 13-Houston Texans 24
The Dolphins lack enough fire power on offense to sufficiently trouble 2011's second-ranked defense. Eventually the Texans offense will wear down Miami's solid defense and pull away in the fourth quarter.
Where To Watch: Dolphins at Texans 1 p.m. ET112527