A trip to the Music City to take on an underrated Tennessee Titans team, represents a tricky opening-day game for the New England Patriots.
Here are three keys to the game and a prediction of the winner:
Patriots must target WR Brandon Lloyd on the outside
New arrival Brandon Lloyd can make the difference for the Patriots offense. The Titans lost a stellar cornerback when Cortland Finnegan signed for the St. Louis Rams in free agency.
With Tennessee's safeties occupied by tight ends Rob Gronkowksi and Aaron Hernandez, Lloyd can win one-on-one matchups on the outside.
Use a five-man front to subdue RB Chris Johnson
He may have endured a mediocre 2011 campaign, but Tennessee rusher Chris Johnson is still one of the most dynamic runners in the NFL.
Agile, fleet of foot and possessing legitimate game-breaking speed, Johnson can torment the Pats' defense and keep the ball away from Tom Brady.
New England had success against the run in last season's playoffs, using a 5-2 Bear defense. The alignment has three big tackles lined up directly over the center and both guards.
Two rush ends set the edges, while two big, run-stuffing inside linebackers fill the gaps. The sheer size of the front eliminates the need to add a safety in the box.
If the Patriots can stay disciplined and maintain their cutback lanes, Johnson will struggle to reach the open field space he thrives in.
The Titans must pressure Brady and force him out of the pocket
Tennessee defensive coordinator Jerry Gray must scheme ways to compensate for a lack of talented pass-rushers. His unit has to pressure Brady and force him away from the pocket.
That means blitzes through the middle. Teams who have had success against Brady have been able to disrupt his timing by moving him off his spot and denying him a clear lane to throw.
It's a risky strategy, but the Patriots simply have too many weapons in the passing game for the Titans to expect to cover them all.
Prediction: New England 28-Tennessee Titans 20
The game will be very close and will expose some of the Patriots vulnerabilities. However, Bill Belichick's team will fashion enough big plays on offense and create a couple of critical turnovers. That will be enough for the win.
Where To Watch: Patriots At Titans, 1 p.m. ET772059