Heading into Week 5, there remained three undefeated teams at 4-0, and the Arizona Cardinals and Atlanta Falcons were two of them. In the weeks that followed the teams fortunes couldn't have been more different. While The Cardinals suffered five back-to-back losses heading into their bye week, the Falcons would extend their unbeaten streak to eight games before finally suffering their first loss in Week 10 to the New Orleans Saints. Coming into the game, the Falcons were clear favorites, but Matt Ryan's interception on the first offensive play of the game, and a quick Cardinals touchdown quickly changed the complexion. The Cardinals built up a 13-0 lead, picking off Ryan twice more and adding two field goals before the end of the first period of play, however, even this was, in many ways, a disappointment. The Cardinals had the chance to put the game to bed early, when starting quarterback John Skelton had star receiver Larry Fitzgerald open in the end zone, but the ball was overthrown, and the Cardinals squandered great field position, which quickly became the theme of the afternoon.